Testosterone trajectories and reference ranges in a large Longitudinal sample of male adolescents

Ammar Khairullah, Laura Klein, Suzanne M. Ingle, Margaret T. May, Courtney A. Whetzel, Elizabeth J. Susman, Tomáš Paus

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Conclusions: The average exposure to testosterone is a useful measure for future investigations using testosterone trajectories to examine pubertal dynamics.

Methods: We carried out longitudinal measurements of plasma testosterone in 2,216 samples obtained from 513 males (9 to 17 years of age) from the Avon Longitudinal Study of Parents and Children. We used integration of a model fitted to each participant's testosterone trajectory to calculate a measure of average exposure to testosterone over adolescence. We pooled these data with corresponding values reported in the literature to provide a reference range of testosterone levels in males between the ages of 6 and 19 years.

Purpose: Pubertal dynamics plays an important role in physical and psychological development of children and adolescents. We aim to provide reference ranges of plasma testosterone in a large longitudinal sample. Furthermore, we describe a measure of testosterone trajectories during adolescence that can be used in future investigations of development.

Results: The average values of total testosterone In the ALSPAC sample range from 0.82 nmol/L (Standard Deviation [SD]: 0.09) at 9 years of age to 16.5 (SD: 2.65) nmol/L at 17 years of age; these values are congruent with other reports In the literature. The average exposure to testosterone is associated with different features of testosterone trajectories such as Peak Testosterone Change, Age at Peak Testosterone Change, and Testosterone at 17 years of age as well as the timing of the growth spurt during puberty.

Original languageEnglish (US)
Article numbere108838
JournalPloS one
Volume9
Issue number9
DOIs
StatePublished - Jan 1 2014

Fingerprint

testosterone
trajectories
Testosterone
Reference Values
Trajectories
sampling
youth development
child development
Adolescent Development
Plasmas
puberty
Puberty
longitudinal studies
Child Development
Longitudinal Studies
Parents
Psychology

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Khairullah, A., Klein, L., Ingle, S. M., May, M. T., Whetzel, C. A., Susman, E. J., & Paus, T. (2014). Testosterone trajectories and reference ranges in a large Longitudinal sample of male adolescents. PloS one, 9(9), [e108838]. https://doi.org/10.1371/journal,pone.0108838
Khairullah, Ammar ; Klein, Laura ; Ingle, Suzanne M. ; May, Margaret T. ; Whetzel, Courtney A. ; Susman, Elizabeth J. ; Paus, Tomáš. / Testosterone trajectories and reference ranges in a large Longitudinal sample of male adolescents. In: PloS one. 2014 ; Vol. 9, No. 9.
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Testosterone trajectories and reference ranges in a large Longitudinal sample of male adolescents. / Khairullah, Ammar; Klein, Laura; Ingle, Suzanne M.; May, Margaret T.; Whetzel, Courtney A.; Susman, Elizabeth J.; Paus, Tomáš.

In: PloS one, Vol. 9, No. 9, e108838, 01.01.2014.

Research output: Contribution to journalArticle

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