Tetrahedron DNA dendrimers and their encapsulation of gold nanoparticles

Tao Zhou, Yijie Wang, Yuanchen Dong, Chun Chen, Dongsheng Liu, Zhongqiang Yang

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


DNA dendrimers have achieved increasing attention recently. Previously reported DNA dendrimers used Y-DNA as monomers. Tetrahedron DNA is a rigid tetrahedral cage made of DNA. Herein, we use tetrahedron DNA as monomers to prepare tetrahedron DNA dendrimers. The prepared tetrahedron DNA dendrimers have larger size compared with those made of Y-DNA. In addition, thanks to the central cavity of tetrahedron DNA monomers, some nanoscale structures (e.g., gold nanoparticles) can be encapsulated within tetrahedron DNA monomers. Tetrahedron DNA encapsulated with gold nanoparticles can be further assembled into dendrimers, guiding gold nanoparticles into clusters.

Original languageEnglish (US)
Pages (from-to)4391-4394
Number of pages4
JournalBioorganic and Medicinal Chemistry
Issue number16
StatePublished - Aug 15 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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