Tetrahydrofuran synthesis via free radical mediated addition of functionalized alkenes to aryl vinyl oxiranes

Ken S. Feldman, Thorsten E. Fisher

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Tri- and tetrasubstituted tetrahydrofuran rings can be prepared by phenylthio radical mediated addition of functionalized alkenes across the carbon-carbon bond of aryl substituted vinyl oxiranes. Studies designed both to delineate the scope and limitations and elucidate the mechanistic course of this process are described.

Original languageEnglish (US)
Pages (from-to)2969-2977
Number of pages9
JournalTetrahedron
Volume45
Issue number10
DOIs
StatePublished - 1989

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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