Tetraploidy in acute myeloid leukemia secondary to large cell lymphoma

S. S. Kaplan, Witold Rybka, J. Blom, S. Shekhter-Levin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A 67 year old male developed a therapy related myelodysplastic process culminating in acute myeloid leukemia 16 years following initial treatment for a large cell lymphoma. A second relapse of this leukemia showed 12% blasts including numerous giant blasts. The presence of giant blasts suggested the possibility of relapsed malignant lymphoma, however, flow cytometry and immunohistochemistry identified them as myeloid and chromosomal analysis revealed a near-tetraploid cell line. No evidence of lymphoma was seen. Although remission was induced with chemotherapy he subsequently relapsed with marrow and/or CNS involvement and was maintained on palliative therapy until he developed sepsis and died, 13 months following the observation of tetraploidy and 33 months following the onset of acute leukemia.

Original languageEnglish (US)
Pages (from-to)617-623
Number of pages7
JournalLeukemia and Lymphoma
Volume31
Issue number5-6
DOIs
StatePublished - Jan 1 1998

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Tetraploidy
Acute Myeloid Leukemia
Lymphoma
Leukemia
Palliative Care
Sepsis
Flow Cytometry
Bone Marrow
Immunohistochemistry
Observation
Recurrence
Drug Therapy
Cell Line
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Kaplan, S. S. ; Rybka, Witold ; Blom, J. ; Shekhter-Levin, S. / Tetraploidy in acute myeloid leukemia secondary to large cell lymphoma. In: Leukemia and Lymphoma. 1998 ; Vol. 31, No. 5-6. pp. 617-623.
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Tetraploidy in acute myeloid leukemia secondary to large cell lymphoma. / Kaplan, S. S.; Rybka, Witold; Blom, J.; Shekhter-Levin, S.

In: Leukemia and Lymphoma, Vol. 31, No. 5-6, 01.01.1998, p. 617-623.

Research output: Contribution to journalArticle

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