TY - JOUR
T1 - Tetrasomy 18p
T2 - Report of cognitive and behavioral characteristics
AU - O'Donnell, Louise
AU - Soileau, Bridgette T.
AU - Sebold, Courtney
AU - Gelfond, Jonathan
AU - Hale, Daniel E.
AU - Cody, Jannine D.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Our purpose was to describe intellectual and behavioral characteristics of persons with tetrasomy 18p. This is a more detailed investigation into the cognitive and behavioral characteristics of our previously reported tetrasomy 18p cohort of 43 plus six additional participants. We evaluated the intellectual functioning using standard measures of cognitive ability, measures of executive functioning, adaptive and maladaptive behaviors. Intellectual abilities ranged from mild impairment/borderline normal to severe/profound impairment calling into question the assumption that severe cognitive limitation is always a feature of tetrasomy 18p. For persons with tetrasomy 18p with mild cognitive deficits, the main barriers to successful functioning stems from limited social and metacognitive skill development and behavior regulation problems rather than being solely determined by cognitive deficits alone.
AB - Our purpose was to describe intellectual and behavioral characteristics of persons with tetrasomy 18p. This is a more detailed investigation into the cognitive and behavioral characteristics of our previously reported tetrasomy 18p cohort of 43 plus six additional participants. We evaluated the intellectual functioning using standard measures of cognitive ability, measures of executive functioning, adaptive and maladaptive behaviors. Intellectual abilities ranged from mild impairment/borderline normal to severe/profound impairment calling into question the assumption that severe cognitive limitation is always a feature of tetrasomy 18p. For persons with tetrasomy 18p with mild cognitive deficits, the main barriers to successful functioning stems from limited social and metacognitive skill development and behavior regulation problems rather than being solely determined by cognitive deficits alone.
UR - http://www.scopus.com/inward/record.url?scp=84931576305&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84931576305&partnerID=8YFLogxK
U2 - 10.1002/ajmg.a.37036
DO - 10.1002/ajmg.a.37036
M3 - Article
C2 - 25900901
AN - SCOPUS:84931576305
VL - 167
SP - 1474
EP - 1482
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
SN - 1552-4825
IS - 7
ER -