TGF-α and IGF-I effects on calcium ion transients in human breast cancer cells

Ransome Etindi, Andrea Manni

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

In order to evaluate the potential role of calcium as an intracellular messenger for IGF-I and TGF-α action on breast cancer cell proliferation, we determined whether these growth factors induce any change in [Ca2+]i using fura-2 loaded cells. The hormone independent BT-20 and MDA-MB-231 cells were refractory to the mitogenic actions of exogenously added IGF-I and TGF-α. TGF-α administration, however, stimulated [Ca2+]i transients in the BT-20 cells. IGF-I and TGF-α stimulated DNA synthesis in the MCF-7 and T47D cells. These growth factors did not, however, stimulate any changes in [Ca2+]i in these cells. These data support the idea that receptor-mediated phospholipid hydrolysis does not serve a major signalling function for driving human breast cancer cells into DNA synthesis.

Original languageEnglish (US)
Pages (from-to)131-137
Number of pages7
JournalCancer Letters
Volume66
Issue number2
DOIs
StatePublished - Sep 30 1992

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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