TGF-β: Its role in the differentiation and function of T regulatory and effector cells

Sujuan Yang, Songguo Zheng

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

The cytokine transforming growth factor-β (TGF-β) plays an important role in the maintenance of T cell homeostasis, immune tolerance to self-antigens, and T cell differentiation during immune responses. TGF-β has pleiotropic effects on adaptive immune responses, especially on the differentiation of T helper and T regulatory cell populations, which depends on the T cell differentiation status and the stimulation conditions. This review provides an update about the roles of TGF-β in T cell responses, especially in the regulation of Treg development and biological features under steady state and inflammation. We also discuss the additional roles that TGF-β plays in the development and function of other T helper cells, such as Th1, Th2, Th9, Th17, and Th22 cells during inflammation.

Original languageEnglish (US)
JournalTurkish Journal of Biology
Volume41
Issue number1
DOIs
StatePublished - 2017

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Physiology
  • Molecular Biology
  • Genetics
  • Agricultural and Biological Sciences(all)
  • Cell Biology

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