Th1 immune response takeover among patients with severe Japanese encephalitis infection

Sujit Kumar Pujhari, Sudesh Prabhakar, Radhakanta Ratho, Baijayantimala Mishra, Manish Modi, Sandeep Sharma, Paramjeet Singh

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The present study was intended to explore the dynamics of viral and host factors determining the outcome of Japanese encephalitis viral infection. 223 patients with acute encephalitic syndrome, 126 with febrile illness suspected of JE and 79 apparently healthy individuals as control were enrolled. Elevated levels of TNF-α and IL-6 in encephalitis patients and IFN-γ in febrile JE patients without encephalitis were observed. A cutoff value of > 55. pg/ml of TNF-α and > 370. pg/ml of IL-6 in CSF was found as poor prognostic marker. Th1 shift (IFN-γ/IL-4: > 1) was observed in encephalitis patients.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalJournal of Neuroimmunology
Volume263
Issue number1-2
DOIs
Publication statusPublished - Oct 15 2013

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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