Th17 cell cytokine secretion profile in host defense and autoimmunity

Kristen E. Graeber, Nancy J. Olsen

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Objective and design: The goal of this review is to examine the effector functions of Th17 cells in host defense and autoimmunity. Material: Published literature on Th17 cells was reviewed with a focus on the secreted products that mediate effector activities of these cells. Results: Th17 cells secrete an array of cytokines that contribute to host defense and that bridge the innate and adaptive arms of the immune response. When this subset of T cells is dysregulated, autoimmune phenomena develop that contribute to the manifestations of many autoimmune diseases. Conclusions: Th17 cells are positioned at a crossroads between innate and adaptive immunity and provide mediators that are essential for host defense. Current interest in harnessing this system for treatment of autoimmune disease will be challenged by the need to avoid abrogating these many protective functions.

Original languageEnglish (US)
Pages (from-to)87-96
Number of pages10
JournalInflammation Research
Volume61
Issue number2
DOIs
StatePublished - Feb 1 2012

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Th17 Cells
Autoimmunity
Cytokines
Adaptive Immunity
Autoimmune Diseases
T-Lymphocyte Subsets
Innate Immunity

All Science Journal Classification (ASJC) codes

  • Immunology
  • Pharmacology

Cite this

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Th17 cell cytokine secretion profile in host defense and autoimmunity. / Graeber, Kristen E.; Olsen, Nancy J.

In: Inflammation Research, Vol. 61, No. 2, 01.02.2012, p. 87-96.

Research output: Contribution to journalReview article

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