The 12 cc Penn State pulsatile pediatric ventricular assist device: Fluid dynamics associated with valve selection

Benjamin T. Cooper, Breigh N. Roszelle, Tobias C. Long, Steven Deutsch, Keefe B. Manning

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The mortality rate for infants awaiting a heart transplant is 40% because of the extremely limited number of donor organs. Ventricular assist devices (VADs), a common bridge-to-transplant solution in adults, are becoming a viable option for pediatric patients. A major obstacle faced by VAD designers is thromboembolism. Previous studies have shown that the interrelated flow characteristics necessary for the prevention of thrombosis in a pulsatile VAD are a strong inlet jet, a late diastolic recirculating flow, and a wall shear rate greater than 500 s-1. Particle image velocimetry was used to compare the flow fields in the chamber of the 12 cc Penn State pediatric pulsatile VAD using two mechanical heart valves: Björk-Shiley monostrut (BSM) tilting disk valves and CarboMedics (CM) bileaflet valves. In conjunction with the flow evaluation, wall shear data were calculated and analyzed to help quantify wall washing. The major orifice inlet jet of the device containing BSM valves was more intense, which led to better recirculation and wall washing than the three jets produced by the CM valves. Regurgitation through the CM valve served as a significant hindrance to the development of the rotational flow.

Original languageEnglish (US)
Article number041019
JournalJournal of Biomechanical Engineering
Volume130
Issue number4
DOIs
StatePublished - Aug 1 2008

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Physiology (medical)

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