The adverse effect of anticonvulsant therapy on renal allograft survival. A preliminary report

Steven J. Wassner, Alfred J. Pennisi, Mohammad H. Malekzadeh, Richard N. Fine

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Administration of anticonvulsant medication to recipients of cadaver renal allografts appears to be associated with decreased allograft survival. The one- and two-year actuarial graft survival rates for 20 index grafts was significantly lower than for 92 control grafts. Since phenobarbital and diphenylhydantoin increase the metabolism of corticosteroids, it is proposed that renal allograft recipients receiving these anticonvulsants may have ineffective immunosuppression, leading to a higher incidence of graft failure.

Original languageEnglish (US)
Pages (from-to)134-137
Number of pages4
JournalThe Journal of Pediatrics
Volume88
Issue number1
DOIs
StatePublished - Jan 1976

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'The adverse effect of anticonvulsant therapy on renal allograft survival. A preliminary report'. Together they form a unique fingerprint.

Cite this