The adverse effect of anticonvulsant therapy on renal allograft survival. A preliminary report

Steven Wassner, Alfred J. Pennisi, Mohammad H. Malekzadeh, Richard N. Fine

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Administration of anticonvulsant medication to recipients of cadaver renal allografts appears to be associated with decreased allograft survival. The one- and two-year actuarial graft survival rates for 20 index grafts was significantly lower than for 92 control grafts. Since phenobarbital and diphenylhydantoin increase the metabolism of corticosteroids, it is proposed that renal allograft recipients receiving these anticonvulsants may have ineffective immunosuppression, leading to a higher incidence of graft failure.

Original languageEnglish (US)
Pages (from-to)134-137
Number of pages4
JournalThe Journal of Pediatrics
Volume88
Issue number1
DOIs
StatePublished - Jan 1 1976

Fingerprint

Anticonvulsants
Allografts
Transplants
Kidney
Phenytoin
Graft Survival
Phenobarbital
Cadaver
Immunosuppression
Adrenal Cortex Hormones
Therapeutics
Incidence

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Wassner, Steven ; Pennisi, Alfred J. ; Malekzadeh, Mohammad H. ; Fine, Richard N. / The adverse effect of anticonvulsant therapy on renal allograft survival. A preliminary report. In: The Journal of Pediatrics. 1976 ; Vol. 88, No. 1. pp. 134-137.
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The adverse effect of anticonvulsant therapy on renal allograft survival. A preliminary report. / Wassner, Steven; Pennisi, Alfred J.; Malekzadeh, Mohammad H.; Fine, Richard N.

In: The Journal of Pediatrics, Vol. 88, No. 1, 01.01.1976, p. 134-137.

Research output: Contribution to journalArticle

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