The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development

B. Kerber, I. Monge, M. Mueller, P. J. Mitchell, S. M. Cohen

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Flies mutant for the Drosophila homologue of the mammalian transcription factor AP-2 show a severe reduction in leg length and fail to develop joint structures. Presumptive joint cells express dAP-2 in response to Notch signaling. dAP-2 is required for joint cell differentiation and can induce formation of supernumerary joints when misexpressed. Although dAP-2 is expressed only in presumptive joint cells, its activity is required to support cell survival in the entire leg segment. Taken together, our data indicate that dAP-2 is an important mediator of Notch activity in leg development.

Original languageEnglish (US)
Pages (from-to)1231-1238
Number of pages8
JournalDevelopment
Volume128
Issue number8
StatePublished - May 17 2001

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Transcription Factor AP-2
Drosophila
Leg
Cell Survival
Joints
Diptera
Cell Differentiation

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology

Cite this

Kerber, B., Monge, I., Mueller, M., Mitchell, P. J., & Cohen, S. M. (2001). The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development. Development, 128(8), 1231-1238.
Kerber, B. ; Monge, I. ; Mueller, M. ; Mitchell, P. J. ; Cohen, S. M. / The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development. In: Development. 2001 ; Vol. 128, No. 8. pp. 1231-1238.
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Kerber, B, Monge, I, Mueller, M, Mitchell, PJ & Cohen, SM 2001, 'The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development', Development, vol. 128, no. 8, pp. 1231-1238.

The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development. / Kerber, B.; Monge, I.; Mueller, M.; Mitchell, P. J.; Cohen, S. M.

In: Development, Vol. 128, No. 8, 17.05.2001, p. 1231-1238.

Research output: Contribution to journalArticle

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Kerber B, Monge I, Mueller M, Mitchell PJ, Cohen SM. The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development. Development. 2001 May 17;128(8):1231-1238.