The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development

B. Kerber, I. Monge, M. Mueller, P. J. Mitchell, S. M. Cohen

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Flies mutant for the Drosophila homologue of the mammalian transcription factor AP-2 show a severe reduction in leg length and fail to develop joint structures. Presumptive joint cells express dAP-2 in response to Notch signaling. dAP-2 is required for joint cell differentiation and can induce formation of supernumerary joints when misexpressed. Although dAP-2 is expressed only in presumptive joint cells, its activity is required to support cell survival in the entire leg segment. Taken together, our data indicate that dAP-2 is an important mediator of Notch activity in leg development.

Original languageEnglish (US)
Pages (from-to)1231-1238
Number of pages8
JournalDevelopment
Volume128
Issue number8
StatePublished - May 17 2001

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology

Fingerprint Dive into the research topics of 'The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development'. Together they form a unique fingerprint.

Cite this