Abstract
Malaria is caused by protozoan parasites of the genus Plasmodium and involves infection of multiple hosts and cell types during the course of an infection. To complete its complex life cycle the parasite requires strict control of gene regulation for survival and successful propagation. Thus far, the Apicomplexan AP2 (ApiAP2) family of DNA-binding proteins is the sole family of proteins to have surfaced as candidate transcription factors in all apicomplexan species. Work from several laboratories is beginning to shed light on how the ApiAP2 proteins from Plasmodium spp. contribute to the regulation of gene expression at various stages of parasite development. Here we highlight recent progress toward understanding the role of Plasmodium ApiAP2 proteins in DNA related regulatory processes including transcriptional regulation and gene silencing.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | Molecular and biochemical parasitology |
| Volume | 176 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 1 2011 |
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All Science Journal Classification (ASJC) codes
- Parasitology
- Molecular Biology
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The Apicomplexan AP2 family : Integral factors regulating Plasmodium development. / Painter, Heather J.; Campbell, Tracey L.; Llinás, Manuel.
In: Molecular and biochemical parasitology, Vol. 176, No. 1, 01.03.2011, p. 1-7.Research output: Contribution to journal › Review article
TY - JOUR
T1 - The Apicomplexan AP2 family
T2 - Integral factors regulating Plasmodium development
AU - Painter, Heather J.
AU - Campbell, Tracey L.
AU - Llinás, Manuel
PY - 2011/3/1
Y1 - 2011/3/1
N2 - Malaria is caused by protozoan parasites of the genus Plasmodium and involves infection of multiple hosts and cell types during the course of an infection. To complete its complex life cycle the parasite requires strict control of gene regulation for survival and successful propagation. Thus far, the Apicomplexan AP2 (ApiAP2) family of DNA-binding proteins is the sole family of proteins to have surfaced as candidate transcription factors in all apicomplexan species. Work from several laboratories is beginning to shed light on how the ApiAP2 proteins from Plasmodium spp. contribute to the regulation of gene expression at various stages of parasite development. Here we highlight recent progress toward understanding the role of Plasmodium ApiAP2 proteins in DNA related regulatory processes including transcriptional regulation and gene silencing.
AB - Malaria is caused by protozoan parasites of the genus Plasmodium and involves infection of multiple hosts and cell types during the course of an infection. To complete its complex life cycle the parasite requires strict control of gene regulation for survival and successful propagation. Thus far, the Apicomplexan AP2 (ApiAP2) family of DNA-binding proteins is the sole family of proteins to have surfaced as candidate transcription factors in all apicomplexan species. Work from several laboratories is beginning to shed light on how the ApiAP2 proteins from Plasmodium spp. contribute to the regulation of gene expression at various stages of parasite development. Here we highlight recent progress toward understanding the role of Plasmodium ApiAP2 proteins in DNA related regulatory processes including transcriptional regulation and gene silencing.
UR - http://www.scopus.com/inward/record.url?scp=78951483348&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78951483348&partnerID=8YFLogxK
U2 - 10.1016/j.molbiopara.2010.11.014
DO - 10.1016/j.molbiopara.2010.11.014
M3 - Review article
C2 - 21126543
AN - SCOPUS:78951483348
VL - 176
SP - 1
EP - 7
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
SN - 0166-6851
IS - 1
ER -