TY - JOUR
T1 - The Apicomplexan AP2 family
T2 - Integral factors regulating Plasmodium development
AU - Painter, Heather J.
AU - Campbell, Tracey L.
AU - Llinás, Manuel
N1 - Funding Information:
We would like to thank Erandi K. De Silva for the critical reading of this manuscript and Rohan Bansal for graphical display of ApiAP2 predicted binding sites. This work was funded by the NIH ( R01 AI076276 ) and the Arnold and Mabel Beckman Foundation with support from the Center for Quantitative Biology ( P50 GM071508 ) (ML). TLC was funded by an NSERC Postdoctoral Fellowship .
PY - 2011/3
Y1 - 2011/3
N2 - Malaria is caused by protozoan parasites of the genus Plasmodium and involves infection of multiple hosts and cell types during the course of an infection. To complete its complex life cycle the parasite requires strict control of gene regulation for survival and successful propagation. Thus far, the Apicomplexan AP2 (ApiAP2) family of DNA-binding proteins is the sole family of proteins to have surfaced as candidate transcription factors in all apicomplexan species. Work from several laboratories is beginning to shed light on how the ApiAP2 proteins from Plasmodium spp. contribute to the regulation of gene expression at various stages of parasite development. Here we highlight recent progress toward understanding the role of Plasmodium ApiAP2 proteins in DNA related regulatory processes including transcriptional regulation and gene silencing.
AB - Malaria is caused by protozoan parasites of the genus Plasmodium and involves infection of multiple hosts and cell types during the course of an infection. To complete its complex life cycle the parasite requires strict control of gene regulation for survival and successful propagation. Thus far, the Apicomplexan AP2 (ApiAP2) family of DNA-binding proteins is the sole family of proteins to have surfaced as candidate transcription factors in all apicomplexan species. Work from several laboratories is beginning to shed light on how the ApiAP2 proteins from Plasmodium spp. contribute to the regulation of gene expression at various stages of parasite development. Here we highlight recent progress toward understanding the role of Plasmodium ApiAP2 proteins in DNA related regulatory processes including transcriptional regulation and gene silencing.
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U2 - 10.1016/j.molbiopara.2010.11.014
DO - 10.1016/j.molbiopara.2010.11.014
M3 - Review article
C2 - 21126543
AN - SCOPUS:78951483348
VL - 176
SP - 1
EP - 7
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
SN - 0166-6851
IS - 1
ER -
