The application of mtDNA SNPs to a forensic case

Kimberly A. Sturk, Michael D. Coble, Suzanne M. Barritt, Thomas John Parsons, Rebecca S. Just

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A multiplex allele specific primer extension (ASPE) assay was optimized to type 11 single nucleotide polymorphisms (SNPs) in the control and coding regions of the mitochondrial genome. The SNPs provide additional discrimination when one of the most common W. European Caucasian hypervariable region types (HV types) is encountered. The SNP assay was applied in a nearly 40-year-old missing persons case involving highly degraded human remains in which four potential reference families matched the case sample across hypervariable regions 1 and 2 (HV1/HV2). The SNP assay identified two coding region positions (5250 and 12438) at which the case sample differed from one reference family. The exclusion eliminated the need for any further testing for comparison to those reference samples, and narrowed the focus to the remaining families.

Original languageEnglish (US)
Pages (from-to)295-297
Number of pages3
JournalForensic Science International: Genetics Supplement Series
Volume1
Issue number1
DOIs
StatePublished - Aug 1 2008

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Mitochondrial DNA
Single Nucleotide Polymorphism
Mitochondrial Genome
Alleles

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Genetics

Cite this

Sturk, K. A., Coble, M. D., Barritt, S. M., Parsons, T. J., & Just, R. S. (2008). The application of mtDNA SNPs to a forensic case. Forensic Science International: Genetics Supplement Series, 1(1), 295-297. https://doi.org/10.1016/j.fsigss.2007.10.148
Sturk, Kimberly A. ; Coble, Michael D. ; Barritt, Suzanne M. ; Parsons, Thomas John ; Just, Rebecca S. / The application of mtDNA SNPs to a forensic case. In: Forensic Science International: Genetics Supplement Series. 2008 ; Vol. 1, No. 1. pp. 295-297.
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The application of mtDNA SNPs to a forensic case. / Sturk, Kimberly A.; Coble, Michael D.; Barritt, Suzanne M.; Parsons, Thomas John; Just, Rebecca S.

In: Forensic Science International: Genetics Supplement Series, Vol. 1, No. 1, 01.08.2008, p. 295-297.

Research output: Contribution to journalArticle

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