The association between autoimmune disorders and chronic granulomatous disease

Neelu Kalra, Gisoo Ghaffari

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by recurrent bacterial and fungal infections, as well as dysregulated granuloma formation. It results from functional defect of the phagocytic nicotinamide adenine dinucleotide phosphate oxidase (NADPH). Autoimmune disorders have been reported more commonly in CGD patients than in the general population. Early diagnosis and management of autoimmune disorders may affect the course of CGD. We present a case of CGD with type 1 diabetes mellitus, a literature review reporting association of CGD and autoimmune diseases, and proposed mechanisms for the pathogenesis of autoimmune diseases in CGD.

Original languageEnglish (US)
Pages (from-to)147-150
Number of pages4
JournalPediatric, Allergy, Immunology, and Pulmonology
Volume27
Issue number3
DOIs
StatePublished - Sep 1 2014

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

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