The association between near-infrared spectroscopy-derived and flow-mediated dilation assessment of vascular responsiveness in the arm

Rogerio N. Soares, Yasina B. Somani, David Nathan Proctor, Juan M. Murias

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction: Following a period of blood flow occlusion, the near-infrared spectroscopy (NIRS)-derived reperfusion slope of the oxygen saturation signal (StO 2 ) is a measure of microvascular responsiveness that has been shown to be positively correlated with flow-mediated dilation (FMD) assessment of conduit artery function in the lower limb vasculature. Given that previously established differences in structure and function of the vessels in the upper compared to the lower limbs may change this relationship, investigating whether this correlation between the reperfusion slope of the StO 2 and the FMD response is maintained in upper limbs is important. Accordingly, this study investigated the correlation between the reperfusion slope of the StO 2 and FMD in the arm vasculature. Methods: 18 physically active individuals were submitted to a vascular occlusion test (VOT). Microvascular responsiveness was calculated as the NIRS-derived reperfusion slope assessed in a forearm muscle. Macrovascular responsiveness was assessed at the brachial artery and calculated as a percent of change in FMD (%FMD). Results: A statistically significant correlation (r = 0.66; P = 0.001) was found between the reperfusion slope and %FMD response. Conclusion: The significant correlation between the reperfusion slope in the forearm muscle and %FMD in the brachial artery, reinforces the relationship between downstream and upstream vascular reactivity in healthy human limbs.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
JournalMicrovascular Research
Volume122
DOIs
StatePublished - Mar 1 2019

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Near infrared spectroscopy
Near-Infrared Spectroscopy
Reperfusion
Blood Vessels
Muscle
Dilatation
Arm
Blood
Brachial Artery
Oxygen
Forearm
Lower Extremity
Muscles
Upper Extremity
Extremities
Arteries

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

Cite this

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title = "The association between near-infrared spectroscopy-derived and flow-mediated dilation assessment of vascular responsiveness in the arm",
abstract = "Introduction: Following a period of blood flow occlusion, the near-infrared spectroscopy (NIRS)-derived reperfusion slope of the oxygen saturation signal (StO 2 ) is a measure of microvascular responsiveness that has been shown to be positively correlated with flow-mediated dilation (FMD) assessment of conduit artery function in the lower limb vasculature. Given that previously established differences in structure and function of the vessels in the upper compared to the lower limbs may change this relationship, investigating whether this correlation between the reperfusion slope of the StO 2 and the FMD response is maintained in upper limbs is important. Accordingly, this study investigated the correlation between the reperfusion slope of the StO 2 and FMD in the arm vasculature. Methods: 18 physically active individuals were submitted to a vascular occlusion test (VOT). Microvascular responsiveness was calculated as the NIRS-derived reperfusion slope assessed in a forearm muscle. Macrovascular responsiveness was assessed at the brachial artery and calculated as a percent of change in FMD ({\%}FMD). Results: A statistically significant correlation (r = 0.66; P = 0.001) was found between the reperfusion slope and {\%}FMD response. Conclusion: The significant correlation between the reperfusion slope in the forearm muscle and {\%}FMD in the brachial artery, reinforces the relationship between downstream and upstream vascular reactivity in healthy human limbs.",
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The association between near-infrared spectroscopy-derived and flow-mediated dilation assessment of vascular responsiveness in the arm. / Soares, Rogerio N.; Somani, Yasina B.; Proctor, David Nathan; Murias, Juan M.

In: Microvascular Research, Vol. 122, 01.03.2019, p. 41-44.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Somani, Yasina B.

AU - Proctor, David Nathan

AU - Murias, Juan M.

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N2 - Introduction: Following a period of blood flow occlusion, the near-infrared spectroscopy (NIRS)-derived reperfusion slope of the oxygen saturation signal (StO 2 ) is a measure of microvascular responsiveness that has been shown to be positively correlated with flow-mediated dilation (FMD) assessment of conduit artery function in the lower limb vasculature. Given that previously established differences in structure and function of the vessels in the upper compared to the lower limbs may change this relationship, investigating whether this correlation between the reperfusion slope of the StO 2 and the FMD response is maintained in upper limbs is important. Accordingly, this study investigated the correlation between the reperfusion slope of the StO 2 and FMD in the arm vasculature. Methods: 18 physically active individuals were submitted to a vascular occlusion test (VOT). Microvascular responsiveness was calculated as the NIRS-derived reperfusion slope assessed in a forearm muscle. Macrovascular responsiveness was assessed at the brachial artery and calculated as a percent of change in FMD (%FMD). Results: A statistically significant correlation (r = 0.66; P = 0.001) was found between the reperfusion slope and %FMD response. Conclusion: The significant correlation between the reperfusion slope in the forearm muscle and %FMD in the brachial artery, reinforces the relationship between downstream and upstream vascular reactivity in healthy human limbs.

AB - Introduction: Following a period of blood flow occlusion, the near-infrared spectroscopy (NIRS)-derived reperfusion slope of the oxygen saturation signal (StO 2 ) is a measure of microvascular responsiveness that has been shown to be positively correlated with flow-mediated dilation (FMD) assessment of conduit artery function in the lower limb vasculature. Given that previously established differences in structure and function of the vessels in the upper compared to the lower limbs may change this relationship, investigating whether this correlation between the reperfusion slope of the StO 2 and the FMD response is maintained in upper limbs is important. Accordingly, this study investigated the correlation between the reperfusion slope of the StO 2 and FMD in the arm vasculature. Methods: 18 physically active individuals were submitted to a vascular occlusion test (VOT). Microvascular responsiveness was calculated as the NIRS-derived reperfusion slope assessed in a forearm muscle. Macrovascular responsiveness was assessed at the brachial artery and calculated as a percent of change in FMD (%FMD). Results: A statistically significant correlation (r = 0.66; P = 0.001) was found between the reperfusion slope and %FMD response. Conclusion: The significant correlation between the reperfusion slope in the forearm muscle and %FMD in the brachial artery, reinforces the relationship between downstream and upstream vascular reactivity in healthy human limbs.

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