The association between single-nucleotide polymorphisms of ORAI1 gene and breast cancer in a Taiwanese population

Wei Chiao Chang, Peng Yeong Woon, Yu Wen Hsu, Shengyu Yang, Yi Ching Chiu, Ming Feng Hou

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background. Breast cancer is the most common malignancy in women. There is increasing evidence suggesting that ORAI1, components of store-operated calcium channel, play a pivotal role in breast cancer progression and metastasis. Methods. A total of 384 female patients with breast cancer were included in this study. We selected five representative tagging ORAI1 SNPs from HapMap database with minimum allele frequency (MAF) ≥ 10%. Genotyping was performed using TaqMan allelic discrimination assay. Chi-square (X2) test was used to analyze statistical differences among control and patient groups in genotype and allelic frequencies. Results. Two of the ORAI1 SNPs (rs12320939 and rs12313273) were associated with estrogen receptors positive in breast cancer patients under the recessive model. When the Bonferroni correction was performed, the significance still existed. In addition, rs12320939 also associated with the lymph nodal involvement. Conclusion. We showed that genetic polymorphisms of ORAI1 associated strongly with lymph nodal involvement and estrogen receptors (ERs) positive breast cancer patients in a Taiwanese population.

Original languageEnglish (US)
Article number916587
JournalThe Scientific World Journal
Volume2012
DOIs
StatePublished - Jul 18 2012

Fingerprint

Polymorphism
Estrogen Receptors
Single Nucleotide Polymorphism
cancer
polymorphism
Nucleotides
Genes
Association reactions
Breast Neoplasms
gene
Calcium Channels
Population
Lymph
Assays
HapMap Project
tagging
Genetic Polymorphisms
Chi-Square Distribution
Gene Frequency
allele

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

Chang, Wei Chiao ; Woon, Peng Yeong ; Hsu, Yu Wen ; Yang, Shengyu ; Chiu, Yi Ching ; Hou, Ming Feng. / The association between single-nucleotide polymorphisms of ORAI1 gene and breast cancer in a Taiwanese population. In: The Scientific World Journal. 2012 ; Vol. 2012.
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abstract = "Background. Breast cancer is the most common malignancy in women. There is increasing evidence suggesting that ORAI1, components of store-operated calcium channel, play a pivotal role in breast cancer progression and metastasis. Methods. A total of 384 female patients with breast cancer were included in this study. We selected five representative tagging ORAI1 SNPs from HapMap database with minimum allele frequency (MAF) ≥ 10{\%}. Genotyping was performed using TaqMan allelic discrimination assay. Chi-square (X2) test was used to analyze statistical differences among control and patient groups in genotype and allelic frequencies. Results. Two of the ORAI1 SNPs (rs12320939 and rs12313273) were associated with estrogen receptors positive in breast cancer patients under the recessive model. When the Bonferroni correction was performed, the significance still existed. In addition, rs12320939 also associated with the lymph nodal involvement. Conclusion. We showed that genetic polymorphisms of ORAI1 associated strongly with lymph nodal involvement and estrogen receptors (ERs) positive breast cancer patients in a Taiwanese population.",
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The association between single-nucleotide polymorphisms of ORAI1 gene and breast cancer in a Taiwanese population. / Chang, Wei Chiao; Woon, Peng Yeong; Hsu, Yu Wen; Yang, Shengyu; Chiu, Yi Ching; Hou, Ming Feng.

In: The Scientific World Journal, Vol. 2012, 916587, 18.07.2012.

Research output: Contribution to journalArticle

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AU - Woon, Peng Yeong

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AU - Chiu, Yi Ching

AU - Hou, Ming Feng

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N2 - Background. Breast cancer is the most common malignancy in women. There is increasing evidence suggesting that ORAI1, components of store-operated calcium channel, play a pivotal role in breast cancer progression and metastasis. Methods. A total of 384 female patients with breast cancer were included in this study. We selected five representative tagging ORAI1 SNPs from HapMap database with minimum allele frequency (MAF) ≥ 10%. Genotyping was performed using TaqMan allelic discrimination assay. Chi-square (X2) test was used to analyze statistical differences among control and patient groups in genotype and allelic frequencies. Results. Two of the ORAI1 SNPs (rs12320939 and rs12313273) were associated with estrogen receptors positive in breast cancer patients under the recessive model. When the Bonferroni correction was performed, the significance still existed. In addition, rs12320939 also associated with the lymph nodal involvement. Conclusion. We showed that genetic polymorphisms of ORAI1 associated strongly with lymph nodal involvement and estrogen receptors (ERs) positive breast cancer patients in a Taiwanese population.

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