The association between skeletal lesions and tuberculosis diagnosis using a probabilistic approach

Dorthe Dangvard Pedersen, George R. Milner, Hans Jørn Kolmos, Jesper Lier Boldsen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Sensitivity and specificity estimates for 18 skeletal lesions were generated from modern skeletons for future paleoepidemiological analyses of tuberculosis prevalence in archaeological samples. A case-control study was conducted using 480 skeletons from 20th century American skeletal collections. One-half of the skeletons were documented tuberculosis cases (Terry Collection). The remaining age and sex-matched skeletons were controls (Bass Collection). The association between 18 candidate skeletal lesions and tuberculosis was established by comparing lesion distributions in case and control groups. Lesion indicators at six locations – visceral surface of ribs, ventral vertebral bodies, lateral part of ilium, acetabular fossa, iliac auricular surface, and ulna olecranon process - occurred significantly more often among cases than in controls, and were associated with one another. The most useful indicator proved to be a bony reaction on ventral thoracic and lumbar vertebral bodies. Its presence means a 53.3% probability of a true tuberculosis diagnosis. Because of the nature of the reference sample – 20th century American cases – sensitivity and specificity estimates will better estimate disease prevalence in archaeological samples from cultural settings where pulmonary tuberculosis predominated. The general approach of this proof-of-concept study is applicable to other diseases that occur commonly and affect bone.

Original languageEnglish (US)
Pages (from-to)88-100
Number of pages13
JournalInternational Journal of Paleopathology
Volume27
DOIs
StatePublished - Dec 2019

Fingerprint

Skeleton
Tuberculosis
Olecranon Process
Ilium
Bass
Sensitivity and Specificity
Ulna
Ribs
Human Body
Pulmonary Tuberculosis
Case-Control Studies
Thorax
Bone and Bones
Control Groups
Lesion
Specificity
Archaeology

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Archaeology

Cite this

Dangvard Pedersen, Dorthe ; Milner, George R. ; Kolmos, Hans Jørn ; Boldsen, Jesper Lier. / The association between skeletal lesions and tuberculosis diagnosis using a probabilistic approach. In: International Journal of Paleopathology. 2019 ; Vol. 27. pp. 88-100.
@article{71947bcf4c3947899959c8bfc14fdde6,
title = "The association between skeletal lesions and tuberculosis diagnosis using a probabilistic approach",
abstract = "Sensitivity and specificity estimates for 18 skeletal lesions were generated from modern skeletons for future paleoepidemiological analyses of tuberculosis prevalence in archaeological samples. A case-control study was conducted using 480 skeletons from 20th century American skeletal collections. One-half of the skeletons were documented tuberculosis cases (Terry Collection). The remaining age and sex-matched skeletons were controls (Bass Collection). The association between 18 candidate skeletal lesions and tuberculosis was established by comparing lesion distributions in case and control groups. Lesion indicators at six locations – visceral surface of ribs, ventral vertebral bodies, lateral part of ilium, acetabular fossa, iliac auricular surface, and ulna olecranon process - occurred significantly more often among cases than in controls, and were associated with one another. The most useful indicator proved to be a bony reaction on ventral thoracic and lumbar vertebral bodies. Its presence means a 53.3{\%} probability of a true tuberculosis diagnosis. Because of the nature of the reference sample – 20th century American cases – sensitivity and specificity estimates will better estimate disease prevalence in archaeological samples from cultural settings where pulmonary tuberculosis predominated. The general approach of this proof-of-concept study is applicable to other diseases that occur commonly and affect bone.",
author = "{Dangvard Pedersen}, Dorthe and Milner, {George R.} and Kolmos, {Hans J{\o}rn} and Boldsen, {Jesper Lier}",
year = "2019",
month = "12",
doi = "10.1016/j.ijpp.2019.01.001",
language = "English (US)",
volume = "27",
pages = "88--100",
journal = "International Journal of Paleopathology",
issn = "1879-9817",
publisher = "Elsevier BV",

}

The association between skeletal lesions and tuberculosis diagnosis using a probabilistic approach. / Dangvard Pedersen, Dorthe; Milner, George R.; Kolmos, Hans Jørn; Boldsen, Jesper Lier.

In: International Journal of Paleopathology, Vol. 27, 12.2019, p. 88-100.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The association between skeletal lesions and tuberculosis diagnosis using a probabilistic approach

AU - Dangvard Pedersen, Dorthe

AU - Milner, George R.

AU - Kolmos, Hans Jørn

AU - Boldsen, Jesper Lier

PY - 2019/12

Y1 - 2019/12

N2 - Sensitivity and specificity estimates for 18 skeletal lesions were generated from modern skeletons for future paleoepidemiological analyses of tuberculosis prevalence in archaeological samples. A case-control study was conducted using 480 skeletons from 20th century American skeletal collections. One-half of the skeletons were documented tuberculosis cases (Terry Collection). The remaining age and sex-matched skeletons were controls (Bass Collection). The association between 18 candidate skeletal lesions and tuberculosis was established by comparing lesion distributions in case and control groups. Lesion indicators at six locations – visceral surface of ribs, ventral vertebral bodies, lateral part of ilium, acetabular fossa, iliac auricular surface, and ulna olecranon process - occurred significantly more often among cases than in controls, and were associated with one another. The most useful indicator proved to be a bony reaction on ventral thoracic and lumbar vertebral bodies. Its presence means a 53.3% probability of a true tuberculosis diagnosis. Because of the nature of the reference sample – 20th century American cases – sensitivity and specificity estimates will better estimate disease prevalence in archaeological samples from cultural settings where pulmonary tuberculosis predominated. The general approach of this proof-of-concept study is applicable to other diseases that occur commonly and affect bone.

AB - Sensitivity and specificity estimates for 18 skeletal lesions were generated from modern skeletons for future paleoepidemiological analyses of tuberculosis prevalence in archaeological samples. A case-control study was conducted using 480 skeletons from 20th century American skeletal collections. One-half of the skeletons were documented tuberculosis cases (Terry Collection). The remaining age and sex-matched skeletons were controls (Bass Collection). The association between 18 candidate skeletal lesions and tuberculosis was established by comparing lesion distributions in case and control groups. Lesion indicators at six locations – visceral surface of ribs, ventral vertebral bodies, lateral part of ilium, acetabular fossa, iliac auricular surface, and ulna olecranon process - occurred significantly more often among cases than in controls, and were associated with one another. The most useful indicator proved to be a bony reaction on ventral thoracic and lumbar vertebral bodies. Its presence means a 53.3% probability of a true tuberculosis diagnosis. Because of the nature of the reference sample – 20th century American cases – sensitivity and specificity estimates will better estimate disease prevalence in archaeological samples from cultural settings where pulmonary tuberculosis predominated. The general approach of this proof-of-concept study is applicable to other diseases that occur commonly and affect bone.

UR - http://www.scopus.com/inward/record.url?scp=85060111114&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060111114&partnerID=8YFLogxK

U2 - 10.1016/j.ijpp.2019.01.001

DO - 10.1016/j.ijpp.2019.01.001

M3 - Article

C2 - 30661884

AN - SCOPUS:85060111114

VL - 27

SP - 88

EP - 100

JO - International Journal of Paleopathology

JF - International Journal of Paleopathology

SN - 1879-9817

ER -