Abstract
This paper discusses “bioink”, bioprintable materials used in three dimensional (3D) bioprinting processes, where cells and other biologics are deposited in a spatially controlled pattern to fabricate living tissues and organs. It presents the first comprehensive review of existing bioink types including hydrogels, cell aggregates, microcarriers and decellularized matrix components used in extrusion-, droplet- and laser-based bioprinting processes. A detailed comparison of these bioink materials is conducted in terms of supporting bioprinting modalities and bioprintability, cell viability and proliferation, biomimicry, resolution, affordability, scalability, practicality, mechanical and structural integrity, bioprinting and post-bioprinting maturation times, tissue fusion and formation post-implantation, degradation characteristics, commercial availability, immune-compatibility, and application areas. The paper then discusses current limitations of bioink materials and presents the future prospects to the reader.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 217-239 |
| Number of pages | 23 |
| Journal | Biotechnology Advances |
| Volume | 35 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1 2017 |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Bioengineering
- Applied Microbiology and Biotechnology
Cite this
}
The bioink : A comprehensive review on bioprintable materials. / Hospodiuk, Monika; Dey, Madhuri; Sosnoski, Donna; Ozbolat, Ibrahim T.
In: Biotechnology Advances, Vol. 35, No. 2, 01.03.2017, p. 217-239.Research output: Contribution to journal › Review article
TY - JOUR
T1 - The bioink
T2 - A comprehensive review on bioprintable materials
AU - Hospodiuk, Monika
AU - Dey, Madhuri
AU - Sosnoski, Donna
AU - Ozbolat, Ibrahim T.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - This paper discusses “bioink”, bioprintable materials used in three dimensional (3D) bioprinting processes, where cells and other biologics are deposited in a spatially controlled pattern to fabricate living tissues and organs. It presents the first comprehensive review of existing bioink types including hydrogels, cell aggregates, microcarriers and decellularized matrix components used in extrusion-, droplet- and laser-based bioprinting processes. A detailed comparison of these bioink materials is conducted in terms of supporting bioprinting modalities and bioprintability, cell viability and proliferation, biomimicry, resolution, affordability, scalability, practicality, mechanical and structural integrity, bioprinting and post-bioprinting maturation times, tissue fusion and formation post-implantation, degradation characteristics, commercial availability, immune-compatibility, and application areas. The paper then discusses current limitations of bioink materials and presents the future prospects to the reader.
AB - This paper discusses “bioink”, bioprintable materials used in three dimensional (3D) bioprinting processes, where cells and other biologics are deposited in a spatially controlled pattern to fabricate living tissues and organs. It presents the first comprehensive review of existing bioink types including hydrogels, cell aggregates, microcarriers and decellularized matrix components used in extrusion-, droplet- and laser-based bioprinting processes. A detailed comparison of these bioink materials is conducted in terms of supporting bioprinting modalities and bioprintability, cell viability and proliferation, biomimicry, resolution, affordability, scalability, practicality, mechanical and structural integrity, bioprinting and post-bioprinting maturation times, tissue fusion and formation post-implantation, degradation characteristics, commercial availability, immune-compatibility, and application areas. The paper then discusses current limitations of bioink materials and presents the future prospects to the reader.
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UR - http://www.scopus.com/inward/citedby.url?scp=85009205030&partnerID=8YFLogxK
U2 - 10.1016/j.biotechadv.2016.12.006
DO - 10.1016/j.biotechadv.2016.12.006
M3 - Review article
C2 - 28057483
AN - SCOPUS:85009205030
VL - 35
SP - 217
EP - 239
JO - Biotechnology Advances
JF - Biotechnology Advances
SN - 0734-9750
IS - 2
ER -