The bioink: A comprehensive review on bioprintable materials

Monika Hospodiuk, Madhuri Dey, Donna Sosnoski, Ibrahim T. Ozbolat

Research output: Contribution to journalReview articlepeer-review

267 Scopus citations

Abstract

This paper discusses “bioink”, bioprintable materials used in three dimensional (3D) bioprinting processes, where cells and other biologics are deposited in a spatially controlled pattern to fabricate living tissues and organs. It presents the first comprehensive review of existing bioink types including hydrogels, cell aggregates, microcarriers and decellularized matrix components used in extrusion-, droplet- and laser-based bioprinting processes. A detailed comparison of these bioink materials is conducted in terms of supporting bioprinting modalities and bioprintability, cell viability and proliferation, biomimicry, resolution, affordability, scalability, practicality, mechanical and structural integrity, bioprinting and post-bioprinting maturation times, tissue fusion and formation post-implantation, degradation characteristics, commercial availability, immune-compatibility, and application areas. The paper then discusses current limitations of bioink materials and presents the future prospects to the reader.

Original languageEnglish (US)
Pages (from-to)217-239
Number of pages23
JournalBiotechnology Advances
Volume35
Issue number2
DOIs
StatePublished - Mar 1 2017

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Fingerprint Dive into the research topics of 'The bioink: A comprehensive review on bioprintable materials'. Together they form a unique fingerprint.

Cite this