TY - JOUR
T1 - The bioink
T2 - A comprehensive review on bioprintable materials
AU - Hospodiuk, Monika
AU - Dey, Madhuri
AU - Sosnoski, Donna
AU - Ozbolat, Ibrahim T.
N1 - Funding Information:
This work has been supported by National Science Foundation CMMI Awards 1349716 and 1462232, and Osteology Foundation Grant # 15042. The authors are grateful to the support from the Engineering Science and Mechanics Department at the Penn State University. The authors confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - This paper discusses “bioink”, bioprintable materials used in three dimensional (3D) bioprinting processes, where cells and other biologics are deposited in a spatially controlled pattern to fabricate living tissues and organs. It presents the first comprehensive review of existing bioink types including hydrogels, cell aggregates, microcarriers and decellularized matrix components used in extrusion-, droplet- and laser-based bioprinting processes. A detailed comparison of these bioink materials is conducted in terms of supporting bioprinting modalities and bioprintability, cell viability and proliferation, biomimicry, resolution, affordability, scalability, practicality, mechanical and structural integrity, bioprinting and post-bioprinting maturation times, tissue fusion and formation post-implantation, degradation characteristics, commercial availability, immune-compatibility, and application areas. The paper then discusses current limitations of bioink materials and presents the future prospects to the reader.
AB - This paper discusses “bioink”, bioprintable materials used in three dimensional (3D) bioprinting processes, where cells and other biologics are deposited in a spatially controlled pattern to fabricate living tissues and organs. It presents the first comprehensive review of existing bioink types including hydrogels, cell aggregates, microcarriers and decellularized matrix components used in extrusion-, droplet- and laser-based bioprinting processes. A detailed comparison of these bioink materials is conducted in terms of supporting bioprinting modalities and bioprintability, cell viability and proliferation, biomimicry, resolution, affordability, scalability, practicality, mechanical and structural integrity, bioprinting and post-bioprinting maturation times, tissue fusion and formation post-implantation, degradation characteristics, commercial availability, immune-compatibility, and application areas. The paper then discusses current limitations of bioink materials and presents the future prospects to the reader.
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U2 - 10.1016/j.biotechadv.2016.12.006
DO - 10.1016/j.biotechadv.2016.12.006
M3 - Review article
C2 - 28057483
AN - SCOPUS:85009205030
VL - 35
SP - 217
EP - 239
JO - Biotechnology Advances
JF - Biotechnology Advances
SN - 0734-9750
IS - 2
ER -