The blood compatibility challenge. Part 3: Material associated activation of blood cascades and cells

Maud Gorbet, Claudia Sperling, Manfred F. Maitz, Christopher Siedlecki, Carsten Werner, Michael V. Sefton

Research output: Contribution to journalReview article

Abstract

Following protein adsorption/activation which is the first step after the contact of material surfaces and whole blood (part 2), fibrinogen is converted to fibrin and platelets become activated and assembled in the form of a thrombus. This thrombus formation is the key feature that needs to be minimized in the creation of materials with low thrombogenicity. Further aspects of blood compatibility that are important on their own are complement and leukocyte activation which are also important drivers of thrombus formation. Hence this review summarizes the state of knowledge on all of these cascades and cells and their interactions. For each cascade or cell type, the chapter distinguishes statements which are in widespread agreement from statements where there is less of a consensus. Statement of Significance: This paper is part 3 of a series of 4 reviews discussing the problem of biomaterial associated thrombogenicity. The objective was to highlight features of broad agreement and provide commentary on those aspects of the problem that were subject to dispute. We hope that future investigators will update these reviews as new scholarship resolves the uncertainties of today.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalActa Biomaterialia
Volume94
DOIs
StatePublished - Aug 1 2019

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Blood Cells
Thrombosis
Blood
Chemical activation
Dissent and Disputes
Complement Activation
Biocompatible Materials
Platelets
Fibrin
Biomaterials
Cell Communication
Fibrinogen
Adsorption
Uncertainty
Consensus
Leukocytes
Blood Platelets
Research Personnel
Proteins

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Cite this

Gorbet, Maud ; Sperling, Claudia ; Maitz, Manfred F. ; Siedlecki, Christopher ; Werner, Carsten ; Sefton, Michael V. / The blood compatibility challenge. Part 3 : Material associated activation of blood cascades and cells. In: Acta Biomaterialia. 2019 ; Vol. 94. pp. 25-32.
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The blood compatibility challenge. Part 3 : Material associated activation of blood cascades and cells. / Gorbet, Maud; Sperling, Claudia; Maitz, Manfred F.; Siedlecki, Christopher; Werner, Carsten; Sefton, Michael V.

In: Acta Biomaterialia, Vol. 94, 01.08.2019, p. 25-32.

Research output: Contribution to journalReview article

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AU - Werner, Carsten

AU - Sefton, Michael V.

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