The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance

M. M. Pretorius, J. V. Gainer, G. P. Van Guilder, E. B. Coelho, J. M. Luther, P. Fong, D. D. Rosenbaum, H. A. Malave, C. Yu, Marylyn Deriggi Ritchie, D. E. Vaughan, N. J. Brown

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We examined the effect of -58 C/T and BE1 +9/-9 polymorphisms in the bradykinin B2 receptor gene on forearm vascular resistance (FVR) before and during intrabrachial artery infusion of the B2 receptor-, endothelium-dependent agonist bradykinin and the endothelium-independent agonist sodium nitroprusside in 228 normotensive subjects. In 166 white Americans, systolic blood pressure (SBP) and pulse pressure were highest in the BE1 +9/+9 group (118±2 and 51±2 mm Hg, respectively; P<0.05 versus -9/-9 for either), intermediate in the +9/-9 group (114±1 and 49±1 mm Hg, P<0.05 versus -9/-9 for pulse pressure), and lowest in the -9/-9 group (110±2 and 44±2 mm Hg). In 62 black Americans, FVR was 25% higher in the BE1 +9/+9 group compared with the BE1 +9/-9 and -9/-9 groups at baseline (P=0.038) or during bradykinin (P=0.03). Increased SBP or vascular resistance may contribute to increased left ventricular mass reported previously in individuals with the BE1+9/+9 genotype.

Original languageEnglish (US)
Pages (from-to)122-129
Number of pages8
JournalClinical pharmacology and therapeutics
Volume83
Issue number1
DOIs
StatePublished - Jan 9 2008

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Bradykinin B2 Receptors
Vascular Resistance
Blood Pressure
Bradykinin
Forearm
Endothelium
Nitroprusside
Arteries
Genotype
Genes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Pretorius, M. M., Gainer, J. V., Van Guilder, G. P., Coelho, E. B., Luther, J. M., Fong, P., ... Brown, N. J. (2008). The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance. Clinical pharmacology and therapeutics, 83(1), 122-129. https://doi.org/10.1038/sj.clpt.6100250
Pretorius, M. M. ; Gainer, J. V. ; Van Guilder, G. P. ; Coelho, E. B. ; Luther, J. M. ; Fong, P. ; Rosenbaum, D. D. ; Malave, H. A. ; Yu, C. ; Ritchie, Marylyn Deriggi ; Vaughan, D. E. ; Brown, N. J. / The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance. In: Clinical pharmacology and therapeutics. 2008 ; Vol. 83, No. 1. pp. 122-129.
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abstract = "We examined the effect of -58 C/T and BE1 +9/-9 polymorphisms in the bradykinin B2 receptor gene on forearm vascular resistance (FVR) before and during intrabrachial artery infusion of the B2 receptor-, endothelium-dependent agonist bradykinin and the endothelium-independent agonist sodium nitroprusside in 228 normotensive subjects. In 166 white Americans, systolic blood pressure (SBP) and pulse pressure were highest in the BE1 +9/+9 group (118±2 and 51±2 mm Hg, respectively; P<0.05 versus -9/-9 for either), intermediate in the +9/-9 group (114±1 and 49±1 mm Hg, P<0.05 versus -9/-9 for pulse pressure), and lowest in the -9/-9 group (110±2 and 44±2 mm Hg). In 62 black Americans, FVR was 25{\%} higher in the BE1 +9/+9 group compared with the BE1 +9/-9 and -9/-9 groups at baseline (P=0.038) or during bradykinin (P=0.03). Increased SBP or vascular resistance may contribute to increased left ventricular mass reported previously in individuals with the BE1+9/+9 genotype.",
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Pretorius, MM, Gainer, JV, Van Guilder, GP, Coelho, EB, Luther, JM, Fong, P, Rosenbaum, DD, Malave, HA, Yu, C, Ritchie, MD, Vaughan, DE & Brown, NJ 2008, 'The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance', Clinical pharmacology and therapeutics, vol. 83, no. 1, pp. 122-129. https://doi.org/10.1038/sj.clpt.6100250

The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance. / Pretorius, M. M.; Gainer, J. V.; Van Guilder, G. P.; Coelho, E. B.; Luther, J. M.; Fong, P.; Rosenbaum, D. D.; Malave, H. A.; Yu, C.; Ritchie, Marylyn Deriggi; Vaughan, D. E.; Brown, N. J.

In: Clinical pharmacology and therapeutics, Vol. 83, No. 1, 09.01.2008, p. 122-129.

Research output: Contribution to journalArticle

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T1 - The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance

AU - Pretorius, M. M.

AU - Gainer, J. V.

AU - Van Guilder, G. P.

AU - Coelho, E. B.

AU - Luther, J. M.

AU - Fong, P.

AU - Rosenbaum, D. D.

AU - Malave, H. A.

AU - Yu, C.

AU - Ritchie, Marylyn Deriggi

AU - Vaughan, D. E.

AU - Brown, N. J.

PY - 2008/1/9

Y1 - 2008/1/9

N2 - We examined the effect of -58 C/T and BE1 +9/-9 polymorphisms in the bradykinin B2 receptor gene on forearm vascular resistance (FVR) before and during intrabrachial artery infusion of the B2 receptor-, endothelium-dependent agonist bradykinin and the endothelium-independent agonist sodium nitroprusside in 228 normotensive subjects. In 166 white Americans, systolic blood pressure (SBP) and pulse pressure were highest in the BE1 +9/+9 group (118±2 and 51±2 mm Hg, respectively; P<0.05 versus -9/-9 for either), intermediate in the +9/-9 group (114±1 and 49±1 mm Hg, P<0.05 versus -9/-9 for pulse pressure), and lowest in the -9/-9 group (110±2 and 44±2 mm Hg). In 62 black Americans, FVR was 25% higher in the BE1 +9/+9 group compared with the BE1 +9/-9 and -9/-9 groups at baseline (P=0.038) or during bradykinin (P=0.03). Increased SBP or vascular resistance may contribute to increased left ventricular mass reported previously in individuals with the BE1+9/+9 genotype.

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