The brain renin-angiotensin system and mitochondrial function: Influence on blood pressure and baroreflex in transgenic rat strains

Manisha Nautiyal, Amy C. Arnold, Mark C. Chappell, Debra I. Diz

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12 Scopus citations

Abstract

Mitochondrial dysfunction is implicated in many cardiovascular diseases, including hypertension, and may be associated with an overactive renin-angiotensin system (RAS). Angiotensin (Ang) II, a potent vasoconstrictor hormone of the RAS, also impairs baroreflex and mitochondrial function. Most deleterious cardiovascular actions of Ang II are thought to be mediated by NADPH-oxidase- (NOX-) derived reactive oxygen species (ROS) that may also stimulate mitochondrial oxidant release and alter redox-sensitive signaling pathways in the brain. Within the RAS, the actions of Ang II are counterbalanced by Ang-(1-7), a vasodilatory peptide known to mitigate against increased oxidant stress. A balance between Ang II and Ang-(1-7) within the brain dorsal medulla contributes to maintenance of normal blood pressure and proper functioning of the arterial baroreceptor reflex for control of heart rate. We propose that Ang-(1-7) may negatively regulate the redox signaling pathways activated by Ang II to maintain normal blood pressure, baroreflex, and mitochondrial function through attenuating ROS (NOX-generated and/or mitochondrial).

Original languageEnglish (US)
Article number136028
JournalInternational Journal of Hypertension
Volume2013
DOIs
Publication statusPublished - Mar 11 2013

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All Science Journal Classification (ASJC) codes

  • Internal Medicine

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