The case for iron chelation and/or antioxidant therapy in Alzheimer's disease

Elise A. Malecki, James Connor

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Iron is involved in the pathogenesis of Alzheimer's disease by multiple mechanisms. We discuss the role of iron in catalysis of reactive oxygen and nitrogen species, protein physical chemistry, and inflammation. Strategies to deal with iron and its effects have a place in the prevention and treatment of Alzheimer's disease. Therapies utilizing these strategies include iron chelators and antioxidants.

Original languageEnglish (US)
Pages (from-to)526-530
Number of pages5
JournalDrug Development Research
Volume56
Issue number3
DOIs
StatePublished - Jul 1 2002

All Science Journal Classification (ASJC) codes

  • Drug Discovery

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