The case for iron chelation and/or antioxidant therapy in Alzheimer's disease

Elise A. Malecki, James Connor

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Iron is involved in the pathogenesis of Alzheimer's disease by multiple mechanisms. We discuss the role of iron in catalysis of reactive oxygen and nitrogen species, protein physical chemistry, and inflammation. Strategies to deal with iron and its effects have a place in the prevention and treatment of Alzheimer's disease. Therapies utilizing these strategies include iron chelators and antioxidants.

Original languageEnglish (US)
Pages (from-to)526-530
Number of pages5
JournalDrug Development Research
Volume56
Issue number3
DOIs
StatePublished - Jul 1 2002

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Alzheimer Disease
Iron
Antioxidants
Physical Chemistry
Reactive Nitrogen Species
Therapeutics
Chelating Agents
Catalysis
Reactive Oxygen Species
Inflammation
Proteins

All Science Journal Classification (ASJC) codes

  • Drug Discovery

Cite this

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The case for iron chelation and/or antioxidant therapy in Alzheimer's disease. / Malecki, Elise A.; Connor, James.

In: Drug Development Research, Vol. 56, No. 3, 01.07.2002, p. 526-530.

Research output: Contribution to journalReview article

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