The cellular immune response of rainbow trout (Salmo gairdneri Richardson) to sheep red blood cells

Vicki Suzette Blazer, R. O. Bennett, R. E. Wolke

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The cellular immune response of rainbow trout, Salmo gairdneri, to sheep erythrocytes was investigated. Both the primary and secondary responses were measured using the migration inhibition factor (MIF), antigen-binding (ABC), and plaque-forming cell (PFC) assays. These immune function assays provide measures of both T and B cell activity. The kinetics of these three responses at 16°C were determined by sampling fish over an 18 day period for the primary response and a ten day period for the secondary response. The peak MIF response occurred two days after injection, while the primary peak PFC reponse was observed 14 days post-injection. Two ABC peaks were observed in the primary response, one at four days and one at ten days after injection. In the secondary response the peak ABC response was observed four days and the peak PFC response six days post-inoculation. The possible interrelationships of the various cell populations are discussed.

Original languageEnglish (US)
Pages (from-to)81-87
Number of pages7
JournalDevelopmental and Comparative Immunology
Volume8
Issue number1
DOIs
StatePublished - Jan 1 1984

All Science Journal Classification (ASJC) codes

  • Immunology
  • Developmental Biology

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