The central clock neurons regulate lipid storage in Drosophila

Justin Robert Diangelo, Renske Erion, Amanda Crocker, Amita Sehgal

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A proper balance of lipid breakdown and synthesis is essential for achieving energy homeostasis as alterations in either of these processes can lead to pathological states such as obesity. The regulation of lipid metabolism is quite complex with multiple signals integrated to control overall triglyceride levels in metabolic tissues. Based upon studies demonstrating effects of the circadian clock on metabolism, we sought to determine if the central clock cells in the Drosophila brain contribute to lipid levels in the fat body, the main nutrient storage organ of the fly. Here, we show that altering the function of the Drosophila central clock neurons leads to an increase in fat body triglycerides. We also show that although triglyceride levels are not affected by age, they are increased by expression of the amyloid-beta protein in central clock neurons. The effect on lipid storage seems to be independent of circadian clock output as changes in triglycerides are not always observed in genetic manipulations that result in altered locomotor rhythms. These data demonstrate that the activity of the central clock neurons is necessary for proper lipid storage.

Original languageEnglish (US)
Article numbere19921
JournalPloS one
Volume6
Issue number5
DOIs
StatePublished - May 24 2011

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Drosophila
Neurons
Clocks
Triglycerides
neurons
triacylglycerols
Lipids
Circadian Clocks
Fat Body
fat body
lipids
circadian rhythm
storage organs
Amyloid beta-Peptides
amyloid
Fats
genetic engineering
Lipid Metabolism
Diptera
lipid metabolism

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Diangelo, Justin Robert ; Erion, Renske ; Crocker, Amanda ; Sehgal, Amita. / The central clock neurons regulate lipid storage in Drosophila. In: PloS one. 2011 ; Vol. 6, No. 5.
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The central clock neurons regulate lipid storage in Drosophila. / Diangelo, Justin Robert; Erion, Renske; Crocker, Amanda; Sehgal, Amita.

In: PloS one, Vol. 6, No. 5, e19921, 24.05.2011.

Research output: Contribution to journalArticle

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