The changing profile of the cardiac donor

Malcolm V. Brock, Jorge D. Salazar, Duke E. Cameron, William A. Baumgartner, John Conte

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Expansion of traditional donor criteria has become standard in most centers. To determine how this has affected donor profiles, at our institution, we reviewed all adult (age ≥ 16) cardiac donors of the past 15 years. Methods: We separated 261 cardiac donors into 2 groups based on time periods: Group I, 1983 to 1991 (n = 131), and Group II, 1991 to 1998 (n = 130). Results: The groups differed significantly in mean donor age (26.2 years vs 30.9; p < 0.001), percent older than 40 years (6% vs 27%; p < 0.001), percent female (23% vs 35%; p = 0.04), percent distant procurement (54% vs 22%; p < 0.001), and percent minority donors (14% vs 29%; p < 0.001). We found an increase in non-traumatic deaths (24% vs 40%; p = 0.008). Older donors had significantly more non-traumatic deaths than younger donors (79% vs 13%; p < 0.001). Overall 5-year survival of recipients was 64% and was not significantly different between our early and late experiences (60% vs 68%; p = not significant [NS]). Recipients with hearts from older donors had a 5-year survival similar to recipients with younger donor hearts (61% vs 64%; p = NS). Traumatic and non-traumatic donors had similar 5-year survivals (64% vs 63%, p = NS). A stepwise multivariate analysis of the entire cohort identified donor age, donor weight, recipient United Network for Organ Sharing status, and cardiopulmonary bypass time as significant independent risk factors for recipient survival. Recipients of hearts from donors < 90 kg had significantly better 5-year survivals than recipients from donors ≥ 90 kg (66% vs 48%; p = 0.01). Conclusions: Our evolving cardiac donor pool now has more minorities, women, and older donors whose deaths are often non-traumatic. At our institution, donor pool expansion has had no adverse effect on the long-term survival of recipients.

Original languageEnglish (US)
Pages (from-to)1005-1009
Number of pages5
JournalJournal of Heart and Lung Transplantation
Volume20
Issue number9
DOIs
StatePublished - Sep 17 2001

Fingerprint

Tissue Donors
Survival
Cardiopulmonary Bypass
Multivariate Analysis
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

Cite this

Brock, M. V., Salazar, J. D., Cameron, D. E., Baumgartner, W. A., & Conte, J. (2001). The changing profile of the cardiac donor. Journal of Heart and Lung Transplantation, 20(9), 1005-1009. https://doi.org/10.1016/S1053-2498(01)00297-2
Brock, Malcolm V. ; Salazar, Jorge D. ; Cameron, Duke E. ; Baumgartner, William A. ; Conte, John. / The changing profile of the cardiac donor. In: Journal of Heart and Lung Transplantation. 2001 ; Vol. 20, No. 9. pp. 1005-1009.
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abstract = "Background: Expansion of traditional donor criteria has become standard in most centers. To determine how this has affected donor profiles, at our institution, we reviewed all adult (age ≥ 16) cardiac donors of the past 15 years. Methods: We separated 261 cardiac donors into 2 groups based on time periods: Group I, 1983 to 1991 (n = 131), and Group II, 1991 to 1998 (n = 130). Results: The groups differed significantly in mean donor age (26.2 years vs 30.9; p < 0.001), percent older than 40 years (6{\%} vs 27{\%}; p < 0.001), percent female (23{\%} vs 35{\%}; p = 0.04), percent distant procurement (54{\%} vs 22{\%}; p < 0.001), and percent minority donors (14{\%} vs 29{\%}; p < 0.001). We found an increase in non-traumatic deaths (24{\%} vs 40{\%}; p = 0.008). Older donors had significantly more non-traumatic deaths than younger donors (79{\%} vs 13{\%}; p < 0.001). Overall 5-year survival of recipients was 64{\%} and was not significantly different between our early and late experiences (60{\%} vs 68{\%}; p = not significant [NS]). Recipients with hearts from older donors had a 5-year survival similar to recipients with younger donor hearts (61{\%} vs 64{\%}; p = NS). Traumatic and non-traumatic donors had similar 5-year survivals (64{\%} vs 63{\%}, p = NS). A stepwise multivariate analysis of the entire cohort identified donor age, donor weight, recipient United Network for Organ Sharing status, and cardiopulmonary bypass time as significant independent risk factors for recipient survival. Recipients of hearts from donors < 90 kg had significantly better 5-year survivals than recipients from donors ≥ 90 kg (66{\%} vs 48{\%}; p = 0.01). Conclusions: Our evolving cardiac donor pool now has more minorities, women, and older donors whose deaths are often non-traumatic. At our institution, donor pool expansion has had no adverse effect on the long-term survival of recipients.",
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Brock, MV, Salazar, JD, Cameron, DE, Baumgartner, WA & Conte, J 2001, 'The changing profile of the cardiac donor', Journal of Heart and Lung Transplantation, vol. 20, no. 9, pp. 1005-1009. https://doi.org/10.1016/S1053-2498(01)00297-2

The changing profile of the cardiac donor. / Brock, Malcolm V.; Salazar, Jorge D.; Cameron, Duke E.; Baumgartner, William A.; Conte, John.

In: Journal of Heart and Lung Transplantation, Vol. 20, No. 9, 17.09.2001, p. 1005-1009.

Research output: Contribution to journalArticle

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T1 - The changing profile of the cardiac donor

AU - Brock, Malcolm V.

AU - Salazar, Jorge D.

AU - Cameron, Duke E.

AU - Baumgartner, William A.

AU - Conte, John

PY - 2001/9/17

Y1 - 2001/9/17

N2 - Background: Expansion of traditional donor criteria has become standard in most centers. To determine how this has affected donor profiles, at our institution, we reviewed all adult (age ≥ 16) cardiac donors of the past 15 years. Methods: We separated 261 cardiac donors into 2 groups based on time periods: Group I, 1983 to 1991 (n = 131), and Group II, 1991 to 1998 (n = 130). Results: The groups differed significantly in mean donor age (26.2 years vs 30.9; p < 0.001), percent older than 40 years (6% vs 27%; p < 0.001), percent female (23% vs 35%; p = 0.04), percent distant procurement (54% vs 22%; p < 0.001), and percent minority donors (14% vs 29%; p < 0.001). We found an increase in non-traumatic deaths (24% vs 40%; p = 0.008). Older donors had significantly more non-traumatic deaths than younger donors (79% vs 13%; p < 0.001). Overall 5-year survival of recipients was 64% and was not significantly different between our early and late experiences (60% vs 68%; p = not significant [NS]). Recipients with hearts from older donors had a 5-year survival similar to recipients with younger donor hearts (61% vs 64%; p = NS). Traumatic and non-traumatic donors had similar 5-year survivals (64% vs 63%, p = NS). A stepwise multivariate analysis of the entire cohort identified donor age, donor weight, recipient United Network for Organ Sharing status, and cardiopulmonary bypass time as significant independent risk factors for recipient survival. Recipients of hearts from donors < 90 kg had significantly better 5-year survivals than recipients from donors ≥ 90 kg (66% vs 48%; p = 0.01). Conclusions: Our evolving cardiac donor pool now has more minorities, women, and older donors whose deaths are often non-traumatic. At our institution, donor pool expansion has had no adverse effect on the long-term survival of recipients.

AB - Background: Expansion of traditional donor criteria has become standard in most centers. To determine how this has affected donor profiles, at our institution, we reviewed all adult (age ≥ 16) cardiac donors of the past 15 years. Methods: We separated 261 cardiac donors into 2 groups based on time periods: Group I, 1983 to 1991 (n = 131), and Group II, 1991 to 1998 (n = 130). Results: The groups differed significantly in mean donor age (26.2 years vs 30.9; p < 0.001), percent older than 40 years (6% vs 27%; p < 0.001), percent female (23% vs 35%; p = 0.04), percent distant procurement (54% vs 22%; p < 0.001), and percent minority donors (14% vs 29%; p < 0.001). We found an increase in non-traumatic deaths (24% vs 40%; p = 0.008). Older donors had significantly more non-traumatic deaths than younger donors (79% vs 13%; p < 0.001). Overall 5-year survival of recipients was 64% and was not significantly different between our early and late experiences (60% vs 68%; p = not significant [NS]). Recipients with hearts from older donors had a 5-year survival similar to recipients with younger donor hearts (61% vs 64%; p = NS). Traumatic and non-traumatic donors had similar 5-year survivals (64% vs 63%, p = NS). A stepwise multivariate analysis of the entire cohort identified donor age, donor weight, recipient United Network for Organ Sharing status, and cardiopulmonary bypass time as significant independent risk factors for recipient survival. Recipients of hearts from donors < 90 kg had significantly better 5-year survivals than recipients from donors ≥ 90 kg (66% vs 48%; p = 0.01). Conclusions: Our evolving cardiac donor pool now has more minorities, women, and older donors whose deaths are often non-traumatic. At our institution, donor pool expansion has had no adverse effect on the long-term survival of recipients.

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