The changing ratio of serum bioactive to immunoreactive follicle-stimulating hormone in normal men following treatment with a potent gonadotropin releasing hormone antagonist

Kristine D. Dah, Spyros N. Pavlou, William J. Kovacs, Aaron J.W. Hsueh

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

Using a recently developed granulosa cell aromatase bioassy (GAB), we measured serum bioactive follicle-stimulating hormone (bio-FSH) levels in 5 normal men after administration of a potent GnRH antagonist. Although only minimal suppression of immunoreactive FSH (immuno-FSH) was detected during administration of 20 mg of the antagonist, ([N-Ac-D-Nal(2)1D-pCl-Phe2 D-Trp3D-h(Arg(Et2)6 D-Ala10]GnRH, pronounced inhibition (79 to89%) of bio-FSH levels occurred. Concomitantly, the ratio of bio- to immuno-FSH levels dramatically decreased within 6 h after antagonist administration. These data reinforce earlier expectations that GnRH antagonists might be potential male contraceptives and provide the first report of changes in circulating bio- to immuno-FSH levels. The GAB assay will facilitate future studies on the biochemical mechanisms by which GnRH antagonists induce changes in the bioactivity of circulating FSH.

Original languageEnglish (US)
Pages (from-to)792-794
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume63
Issue number3
DOIs
StatePublished - Sep 1986

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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