The choroid plexus as a site of damage in hemorrhagic and ischemic stroke and its role in responding to injury

Jianming Xiang, Lisa J. Routhe, D. Andrew Wilkinson, Ya Hua, Torben Moos, Guohua Xi, Richard F. Keep

Research output: Contribution to journalReview articlepeer-review

Abstract

While the impact of hemorrhasgic and ischemic strokes on the blood-brain barrier has been extensively studied, the impact of these types of stroke on the choroid plexus, site of the blood-CSF barrier, has received much less attention. The purpose of this review is to examine evidence of choroid plexus injury in clinical and preclinical studies of intraventricular hemorrhage, subarachnoid hemorrhage, intracerebral hemorrhage and ischemic stroke. It then discusses evidence that the choroid plexuses are important in the response to brain injury, with potential roles in limiting damage. The overall aim of the review is to highlight deficiencies in our knowledge on the impact of hemorrhagic and ischemic strokes on the choroid plexus, particularly with reference to intraventricular hemorrhage, and to suggest that a greater understanding of the response of the choroid plexus to stroke may open new avenues for brain protection.

Original languageEnglish (US)
Article number8
JournalFluids and Barriers of the CNS
Volume14
Issue number1
DOIs
StatePublished - Mar 28 2017

All Science Journal Classification (ASJC) codes

  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

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