TY - JOUR
T1 - The choroid plexus as a site of damage in hemorrhagic and ischemic stroke and its role in responding to injury
AU - Xiang, Jianming
AU - Routhe, Lisa J.
AU - Andrew Wilkinson, D.
AU - Hua, Ya
AU - Moos, Torben
AU - Xi, Guohua
AU - Keep, Richard F.
N1 - Funding Information:
Not applicable. This work was supported by the National Institutes of Health Grants NS073595, NS079157, NS090925, NS091545, NS093399, NS096917 and NS007222. The
Publisher Copyright:
© 2017 The Author(s).
PY - 2017/3/28
Y1 - 2017/3/28
N2 - While the impact of hemorrhasgic and ischemic strokes on the blood-brain barrier has been extensively studied, the impact of these types of stroke on the choroid plexus, site of the blood-CSF barrier, has received much less attention. The purpose of this review is to examine evidence of choroid plexus injury in clinical and preclinical studies of intraventricular hemorrhage, subarachnoid hemorrhage, intracerebral hemorrhage and ischemic stroke. It then discusses evidence that the choroid plexuses are important in the response to brain injury, with potential roles in limiting damage. The overall aim of the review is to highlight deficiencies in our knowledge on the impact of hemorrhagic and ischemic strokes on the choroid plexus, particularly with reference to intraventricular hemorrhage, and to suggest that a greater understanding of the response of the choroid plexus to stroke may open new avenues for brain protection.
AB - While the impact of hemorrhasgic and ischemic strokes on the blood-brain barrier has been extensively studied, the impact of these types of stroke on the choroid plexus, site of the blood-CSF barrier, has received much less attention. The purpose of this review is to examine evidence of choroid plexus injury in clinical and preclinical studies of intraventricular hemorrhage, subarachnoid hemorrhage, intracerebral hemorrhage and ischemic stroke. It then discusses evidence that the choroid plexuses are important in the response to brain injury, with potential roles in limiting damage. The overall aim of the review is to highlight deficiencies in our knowledge on the impact of hemorrhagic and ischemic strokes on the choroid plexus, particularly with reference to intraventricular hemorrhage, and to suggest that a greater understanding of the response of the choroid plexus to stroke may open new avenues for brain protection.
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U2 - 10.1186/s12987-017-0056-3
DO - 10.1186/s12987-017-0056-3
M3 - Review article
C2 - 28351417
AN - SCOPUS:85016463916
VL - 14
JO - Fluids and Barriers of the CNS
JF - Fluids and Barriers of the CNS
SN - 2045-8118
IS - 1
M1 - 8
ER -