The circadian pattern of cardiac autonomic modulation in a middle-aged population

Xian Li, Michele L. Shaffer, Sol Rodriguez-Colon, Fan He, Deborah L. Wolbrette, Peter Alagona, Chuntao Wu, Duanping Liao

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objectives: To examine the circadian pattern of cardiac autonomic modulation (CAM) and its attributes in general population. Methods: We obtained 24-h beat-to-beat RR data using a high resolution 12-lead Holter ECG in a community-dwelling sample of 115 non-smokers. We performed heart rate variability (HRV) analysis on the normal RRs from each 5-min segment to obtain time-specific HRV indices: high (HF; 0.15-0.40 Hz) and low (LF; 0.04-0.15 Hz) frequency powers, standard deviation of RR intervals (SDNN), and the square root of the mean of the sum of the squared differences of the adjacent RR intervals (RMSSD). For each individual, we fit the segment-specific HRV data to a cosine periodic function, and estimated 3 individual-level cosine function parameters to quantify the circadian variation: the mean (M), amplitude (A), and acrophase (θ). We then used a random-effects meta-analysis to summarize the M, A, and θ, and their 95% confidence intervals (CI). Results: The mean age was 56 (SD 8) years, with 63% female and 76% white. The averages of M, A and θ (95%CI) of log HF were 3.59 (3.43-3.76) ms2, 0.61 (0.54-0.68) ms2, and 3:10 (2:25-3:55) AM, respectively, and that of RMSSD were 22.3 (20.5-24.1) ms, 6.5 (5.4-7.5) ms, 3:45 (2:55-4:35) AM, respectively. Older age is associated with lower mean of HRV. Males have higher oscillation amplitude than females. The acrophase of LF/HF was earlier in females than in males, and in younger individuals than in older individuals. Conclusions: The circadian pattern of CAM can be quantified by 3 cosine parameters of HRV, which are correlated with age and gender.

Original languageEnglish (US)
Pages (from-to)143-150
Number of pages8
JournalClinical Autonomic Research
Volume21
Issue number3
DOIs
StatePublished - Jun 1 2011

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Heart Rate
Population
Confidence Intervals
Independent Living
Meta-Analysis
Electrocardiography

All Science Journal Classification (ASJC) codes

  • Endocrine and Autonomic Systems
  • Clinical Neurology

Cite this

Li, Xian ; Shaffer, Michele L. ; Rodriguez-Colon, Sol ; He, Fan ; Wolbrette, Deborah L. ; Alagona, Peter ; Wu, Chuntao ; Liao, Duanping. / The circadian pattern of cardiac autonomic modulation in a middle-aged population. In: Clinical Autonomic Research. 2011 ; Vol. 21, No. 3. pp. 143-150.
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abstract = "Objectives: To examine the circadian pattern of cardiac autonomic modulation (CAM) and its attributes in general population. Methods: We obtained 24-h beat-to-beat RR data using a high resolution 12-lead Holter ECG in a community-dwelling sample of 115 non-smokers. We performed heart rate variability (HRV) analysis on the normal RRs from each 5-min segment to obtain time-specific HRV indices: high (HF; 0.15-0.40 Hz) and low (LF; 0.04-0.15 Hz) frequency powers, standard deviation of RR intervals (SDNN), and the square root of the mean of the sum of the squared differences of the adjacent RR intervals (RMSSD). For each individual, we fit the segment-specific HRV data to a cosine periodic function, and estimated 3 individual-level cosine function parameters to quantify the circadian variation: the mean (M), amplitude (A), and acrophase (θ). We then used a random-effects meta-analysis to summarize the M, A, and θ, and their 95{\%} confidence intervals (CI). Results: The mean age was 56 (SD 8) years, with 63{\%} female and 76{\%} white. The averages of M, A and θ (95{\%}CI) of log HF were 3.59 (3.43-3.76) ms2, 0.61 (0.54-0.68) ms2, and 3:10 (2:25-3:55) AM, respectively, and that of RMSSD were 22.3 (20.5-24.1) ms, 6.5 (5.4-7.5) ms, 3:45 (2:55-4:35) AM, respectively. Older age is associated with lower mean of HRV. Males have higher oscillation amplitude than females. The acrophase of LF/HF was earlier in females than in males, and in younger individuals than in older individuals. Conclusions: The circadian pattern of CAM can be quantified by 3 cosine parameters of HRV, which are correlated with age and gender.",
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The circadian pattern of cardiac autonomic modulation in a middle-aged population. / Li, Xian; Shaffer, Michele L.; Rodriguez-Colon, Sol; He, Fan; Wolbrette, Deborah L.; Alagona, Peter; Wu, Chuntao; Liao, Duanping.

In: Clinical Autonomic Research, Vol. 21, No. 3, 01.06.2011, p. 143-150.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The circadian pattern of cardiac autonomic modulation in a middle-aged population

AU - Li, Xian

AU - Shaffer, Michele L.

AU - Rodriguez-Colon, Sol

AU - He, Fan

AU - Wolbrette, Deborah L.

AU - Alagona, Peter

AU - Wu, Chuntao

AU - Liao, Duanping

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N2 - Objectives: To examine the circadian pattern of cardiac autonomic modulation (CAM) and its attributes in general population. Methods: We obtained 24-h beat-to-beat RR data using a high resolution 12-lead Holter ECG in a community-dwelling sample of 115 non-smokers. We performed heart rate variability (HRV) analysis on the normal RRs from each 5-min segment to obtain time-specific HRV indices: high (HF; 0.15-0.40 Hz) and low (LF; 0.04-0.15 Hz) frequency powers, standard deviation of RR intervals (SDNN), and the square root of the mean of the sum of the squared differences of the adjacent RR intervals (RMSSD). For each individual, we fit the segment-specific HRV data to a cosine periodic function, and estimated 3 individual-level cosine function parameters to quantify the circadian variation: the mean (M), amplitude (A), and acrophase (θ). We then used a random-effects meta-analysis to summarize the M, A, and θ, and their 95% confidence intervals (CI). Results: The mean age was 56 (SD 8) years, with 63% female and 76% white. The averages of M, A and θ (95%CI) of log HF were 3.59 (3.43-3.76) ms2, 0.61 (0.54-0.68) ms2, and 3:10 (2:25-3:55) AM, respectively, and that of RMSSD were 22.3 (20.5-24.1) ms, 6.5 (5.4-7.5) ms, 3:45 (2:55-4:35) AM, respectively. Older age is associated with lower mean of HRV. Males have higher oscillation amplitude than females. The acrophase of LF/HF was earlier in females than in males, and in younger individuals than in older individuals. Conclusions: The circadian pattern of CAM can be quantified by 3 cosine parameters of HRV, which are correlated with age and gender.

AB - Objectives: To examine the circadian pattern of cardiac autonomic modulation (CAM) and its attributes in general population. Methods: We obtained 24-h beat-to-beat RR data using a high resolution 12-lead Holter ECG in a community-dwelling sample of 115 non-smokers. We performed heart rate variability (HRV) analysis on the normal RRs from each 5-min segment to obtain time-specific HRV indices: high (HF; 0.15-0.40 Hz) and low (LF; 0.04-0.15 Hz) frequency powers, standard deviation of RR intervals (SDNN), and the square root of the mean of the sum of the squared differences of the adjacent RR intervals (RMSSD). For each individual, we fit the segment-specific HRV data to a cosine periodic function, and estimated 3 individual-level cosine function parameters to quantify the circadian variation: the mean (M), amplitude (A), and acrophase (θ). We then used a random-effects meta-analysis to summarize the M, A, and θ, and their 95% confidence intervals (CI). Results: The mean age was 56 (SD 8) years, with 63% female and 76% white. The averages of M, A and θ (95%CI) of log HF were 3.59 (3.43-3.76) ms2, 0.61 (0.54-0.68) ms2, and 3:10 (2:25-3:55) AM, respectively, and that of RMSSD were 22.3 (20.5-24.1) ms, 6.5 (5.4-7.5) ms, 3:45 (2:55-4:35) AM, respectively. Older age is associated with lower mean of HRV. Males have higher oscillation amplitude than females. The acrophase of LF/HF was earlier in females than in males, and in younger individuals than in older individuals. Conclusions: The circadian pattern of CAM can be quantified by 3 cosine parameters of HRV, which are correlated with age and gender.

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