The Clinical Spectrum and Manifestations of Acute Liver Failure

Sarah Zahra Maher, Ian Schreibman

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Acute liver failure (ALF) is a rare life-threatening condition characterized by rapid progression and death. Causes vary according to geographic region, with acetaminophen and drug-induced ALF being the most common causes in the United States. Determining the cause aids in predicting the prognosis and the presentation of manifestations and guides providers to perform cause-specific management. At initial presentation, nonspecific symptoms are present but may progress to complications, including cerebral edema, infection, coagulopathy, renal failure, cardiopulmonary failure, and acid-base and/or metabolic disturbances. Although some cases of ALF resolve with conservative measures, liver transplantation is the ultimate treatment in many cases.

Original languageEnglish (US)
Pages (from-to)361-374
Number of pages14
JournalClinics in Liver Disease
Volume22
Issue number2
DOIs
StatePublished - May 1 2018

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Acute Liver Failure
Brain Edema
Acetaminophen
Liver Transplantation
Renal Insufficiency
Acids
Infection
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

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title = "The Clinical Spectrum and Manifestations of Acute Liver Failure",
abstract = "Acute liver failure (ALF) is a rare life-threatening condition characterized by rapid progression and death. Causes vary according to geographic region, with acetaminophen and drug-induced ALF being the most common causes in the United States. Determining the cause aids in predicting the prognosis and the presentation of manifestations and guides providers to perform cause-specific management. At initial presentation, nonspecific symptoms are present but may progress to complications, including cerebral edema, infection, coagulopathy, renal failure, cardiopulmonary failure, and acid-base and/or metabolic disturbances. Although some cases of ALF resolve with conservative measures, liver transplantation is the ultimate treatment in many cases.",
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The Clinical Spectrum and Manifestations of Acute Liver Failure. / Maher, Sarah Zahra; Schreibman, Ian.

In: Clinics in Liver Disease, Vol. 22, No. 2, 01.05.2018, p. 361-374.

Research output: Contribution to journalReview article

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T1 - The Clinical Spectrum and Manifestations of Acute Liver Failure

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AU - Schreibman, Ian

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AB - Acute liver failure (ALF) is a rare life-threatening condition characterized by rapid progression and death. Causes vary according to geographic region, with acetaminophen and drug-induced ALF being the most common causes in the United States. Determining the cause aids in predicting the prognosis and the presentation of manifestations and guides providers to perform cause-specific management. At initial presentation, nonspecific symptoms are present but may progress to complications, including cerebral edema, infection, coagulopathy, renal failure, cardiopulmonary failure, and acid-base and/or metabolic disturbances. Although some cases of ALF resolve with conservative measures, liver transplantation is the ultimate treatment in many cases.

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