The contribution of local factors to the elevated venous tone of congestive heart failure

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Abstract

Since the concept of an elevated venous tone in congestive heart failure (CHF) has been recently questioned, the venous volume of the elevated calf at a venous pressure of 30 mm Hg (VV[30]) was determined in 18 normal volunteers (N) and 10 CHF patients with a mercury in rubber strain gauge plethysmograph. CHF patients had a significantly lower VV[30] at rest and after intra arterial phentolamine (2 mg) than normal subjects, suggesting that in these patients a state of peripheral venoconstriction existed (rest N: 4.63±0.17, CHF: 1.7±0.23 ml/100 ml, P<0.01; pre and postphentolamine N: 4.85±0.21 to 4.95±0.31, CHF: 2.26±0.29 to 2.68±0.38 ml/100 ml, P<0.01). Alpha adrenergic blockade failed to increase VV[30] significantly in N, but did increase it in CHF (P<0.05), suggesting that part of the decreased VV[30] in CHF is due to an augmented sympathoadrenal discharge. When sodium nitrite (30 mg) was given as a single intra arterial injection before or after phentolamine or when given in 4 successive doses at 3 min intervals, the VV[30] of CHF patients was never increased to more than 3.62±0.42 ml/100 ml and was always less than N (P<0.01). VV[30] in CHF after these interventions was even significantly less than that of N before intervention (P<0.05), suggesting that factors other than local active smooth muscle venoconstriction were operative in CHF to lower VV[30]. It is suggested that perhaps clinically undetectable edema and an elevated tissue pressure may account for these differences.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalJournal of Clinical Investigation
Volume54
Issue number2
DOIs
StatePublished - Jan 1 1974

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Heart Failure
Phentolamine
Sodium Nitrite
Intra-Arterial Injections
Venous Pressure
Rubber
Mercury
Adrenergic Agents
Smooth Muscle
Edema
Healthy Volunteers
Pressure

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "The contribution of local factors to the elevated venous tone of congestive heart failure",
abstract = "Since the concept of an elevated venous tone in congestive heart failure (CHF) has been recently questioned, the venous volume of the elevated calf at a venous pressure of 30 mm Hg (VV[30]) was determined in 18 normal volunteers (N) and 10 CHF patients with a mercury in rubber strain gauge plethysmograph. CHF patients had a significantly lower VV[30] at rest and after intra arterial phentolamine (2 mg) than normal subjects, suggesting that in these patients a state of peripheral venoconstriction existed (rest N: 4.63±0.17, CHF: 1.7±0.23 ml/100 ml, P<0.01; pre and postphentolamine N: 4.85±0.21 to 4.95±0.31, CHF: 2.26±0.29 to 2.68±0.38 ml/100 ml, P<0.01). Alpha adrenergic blockade failed to increase VV[30] significantly in N, but did increase it in CHF (P<0.05), suggesting that part of the decreased VV[30] in CHF is due to an augmented sympathoadrenal discharge. When sodium nitrite (30 mg) was given as a single intra arterial injection before or after phentolamine or when given in 4 successive doses at 3 min intervals, the VV[30] of CHF patients was never increased to more than 3.62±0.42 ml/100 ml and was always less than N (P<0.01). VV[30] in CHF after these interventions was even significantly less than that of N before intervention (P<0.05), suggesting that factors other than local active smooth muscle venoconstriction were operative in CHF to lower VV[30]. It is suggested that perhaps clinically undetectable edema and an elevated tissue pressure may account for these differences.",
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The contribution of local factors to the elevated venous tone of congestive heart failure. / Zelis, Robert.

In: Journal of Clinical Investigation, Vol. 54, No. 2, 01.01.1974, p. 219-224.

Research output: Contribution to journalArticle

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AU - Zelis, Robert

PY - 1974/1/1

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AB - Since the concept of an elevated venous tone in congestive heart failure (CHF) has been recently questioned, the venous volume of the elevated calf at a venous pressure of 30 mm Hg (VV[30]) was determined in 18 normal volunteers (N) and 10 CHF patients with a mercury in rubber strain gauge plethysmograph. CHF patients had a significantly lower VV[30] at rest and after intra arterial phentolamine (2 mg) than normal subjects, suggesting that in these patients a state of peripheral venoconstriction existed (rest N: 4.63±0.17, CHF: 1.7±0.23 ml/100 ml, P<0.01; pre and postphentolamine N: 4.85±0.21 to 4.95±0.31, CHF: 2.26±0.29 to 2.68±0.38 ml/100 ml, P<0.01). Alpha adrenergic blockade failed to increase VV[30] significantly in N, but did increase it in CHF (P<0.05), suggesting that part of the decreased VV[30] in CHF is due to an augmented sympathoadrenal discharge. When sodium nitrite (30 mg) was given as a single intra arterial injection before or after phentolamine or when given in 4 successive doses at 3 min intervals, the VV[30] of CHF patients was never increased to more than 3.62±0.42 ml/100 ml and was always less than N (P<0.01). VV[30] in CHF after these interventions was even significantly less than that of N before intervention (P<0.05), suggesting that factors other than local active smooth muscle venoconstriction were operative in CHF to lower VV[30]. It is suggested that perhaps clinically undetectable edema and an elevated tissue pressure may account for these differences.

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