The coordinated evolution of yeast proteins is constrained by functional modularity

Yiwen Chen, Nikolay Dokholyan

Research output: Contribution to journalShort surveypeer-review

50 Scopus citations

Abstract

Functional modularity is a key attribute of cellular systems and has important roles in evolution. However, the extent to which functional modularity affects protein evolution is largely unknown. Here, we analyzed the evolution of both sequence and expression level of proteins in the yeast Saccharomyces cerevisiae and found that proteins within the same functional modules evolve at more similar rates than those between different modules. We also found stronger co-evolution of expression levels between proteins within functional modules than between them. These results suggest that a coordinated evolution of both the sequence and expression level of proteins is constrained by functional modularity.

Original languageEnglish (US)
Pages (from-to)416-419
Number of pages4
JournalTrends in Genetics
Volume22
Issue number8
DOIs
StatePublished - Aug 1 2006

All Science Journal Classification (ASJC) codes

  • Genetics

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