The critical chemical and mechanical regulation of folic acid on neural engineering

Gloria B. Kim, Yongjie Chen, Weibo Kang, Jinshan Guo, Russell Payne, Hui Li, Qiong Wei, Julianne Baker, Cheng Dong, Sulin Zhang, Pak Kin Wong, Elias Rizk, Jiazhi Yan, Jian Yang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The mandate of folic acid supplementation in grained products has reduced the occurrence of neural tube defects by one third in the U.S since its introduction by the Food and Drug Administration in 1998. However, the advantages and possible mechanisms of action of using folic acid for peripheral nerve engineering and neurological diseases still remain largely elusive. Herein, folic acid is described as an inexpensive and multifunctional niche component that modulates behaviors in different cells in the nervous system. The multiple benefits of modulation include: 1) generating chemotactic responses on glial cells, 2) inducing neurotrophin release, and 3) stimulating neuronal differentiation of a PC-12 cell system. For the first time, folic acid is also shown to enhance cellular force generation and global methylation in the PC-12 cells, thereby enabling both biomechanical and biochemical pathways to regulate neuron differentiation. These findings are evaluated in vivo for clinical translation. Our results suggest that folic acid-nerve guidance conduits may offer significant benefits as a low-cost, off-the-shelf product for reaching the functional recovery seen with autografts in large sciatic nerve defects. Consequently, folic acid holds great potential as a critical and convenient therapeutic intervention for neural engineering, regenerative medicine, medical prosthetics, and drug delivery.

Original languageEnglish (US)
Pages (from-to)504-516
Number of pages13
JournalBiomaterials
Volume178
DOIs
StatePublished - Sep 1 2018

Fingerprint

Folic Acid
Acids
Neurotrophin 3
Defects
Regenerative Medicine
Methylation
Neural Tube Defects
Autografts
Nerve Growth Factors
Neurology
Sciatic Nerve
United States Food and Drug Administration
Prosthetics
Drug delivery
Peripheral Nerves
Neuroglia
Nervous System
Neurons
Modulation
Costs and Cost Analysis

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Kim, Gloria B. ; Chen, Yongjie ; Kang, Weibo ; Guo, Jinshan ; Payne, Russell ; Li, Hui ; Wei, Qiong ; Baker, Julianne ; Dong, Cheng ; Zhang, Sulin ; Wong, Pak Kin ; Rizk, Elias ; Yan, Jiazhi ; Yang, Jian. / The critical chemical and mechanical regulation of folic acid on neural engineering. In: Biomaterials. 2018 ; Vol. 178. pp. 504-516.
@article{31886519e156474c98393089d5a0758b,
title = "The critical chemical and mechanical regulation of folic acid on neural engineering",
abstract = "The mandate of folic acid supplementation in grained products has reduced the occurrence of neural tube defects by one third in the U.S since its introduction by the Food and Drug Administration in 1998. However, the advantages and possible mechanisms of action of using folic acid for peripheral nerve engineering and neurological diseases still remain largely elusive. Herein, folic acid is described as an inexpensive and multifunctional niche component that modulates behaviors in different cells in the nervous system. The multiple benefits of modulation include: 1) generating chemotactic responses on glial cells, 2) inducing neurotrophin release, and 3) stimulating neuronal differentiation of a PC-12 cell system. For the first time, folic acid is also shown to enhance cellular force generation and global methylation in the PC-12 cells, thereby enabling both biomechanical and biochemical pathways to regulate neuron differentiation. These findings are evaluated in vivo for clinical translation. Our results suggest that folic acid-nerve guidance conduits may offer significant benefits as a low-cost, off-the-shelf product for reaching the functional recovery seen with autografts in large sciatic nerve defects. Consequently, folic acid holds great potential as a critical and convenient therapeutic intervention for neural engineering, regenerative medicine, medical prosthetics, and drug delivery.",
author = "Kim, {Gloria B.} and Yongjie Chen and Weibo Kang and Jinshan Guo and Russell Payne and Hui Li and Qiong Wei and Julianne Baker and Cheng Dong and Sulin Zhang and Wong, {Pak Kin} and Elias Rizk and Jiazhi Yan and Jian Yang",
year = "2018",
month = "9",
day = "1",
doi = "10.1016/j.biomaterials.2018.03.059",
language = "English (US)",
volume = "178",
pages = "504--516",
journal = "Biomaterials",
issn = "0142-9612",
publisher = "Elsevier BV",

}

Kim, GB, Chen, Y, Kang, W, Guo, J, Payne, R, Li, H, Wei, Q, Baker, J, Dong, C, Zhang, S, Wong, PK, Rizk, E, Yan, J & Yang, J 2018, 'The critical chemical and mechanical regulation of folic acid on neural engineering', Biomaterials, vol. 178, pp. 504-516. https://doi.org/10.1016/j.biomaterials.2018.03.059

The critical chemical and mechanical regulation of folic acid on neural engineering. / Kim, Gloria B.; Chen, Yongjie; Kang, Weibo; Guo, Jinshan; Payne, Russell; Li, Hui; Wei, Qiong; Baker, Julianne; Dong, Cheng; Zhang, Sulin; Wong, Pak Kin; Rizk, Elias; Yan, Jiazhi; Yang, Jian.

In: Biomaterials, Vol. 178, 01.09.2018, p. 504-516.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The critical chemical and mechanical regulation of folic acid on neural engineering

AU - Kim, Gloria B.

AU - Chen, Yongjie

AU - Kang, Weibo

AU - Guo, Jinshan

AU - Payne, Russell

AU - Li, Hui

AU - Wei, Qiong

AU - Baker, Julianne

AU - Dong, Cheng

AU - Zhang, Sulin

AU - Wong, Pak Kin

AU - Rizk, Elias

AU - Yan, Jiazhi

AU - Yang, Jian

PY - 2018/9/1

Y1 - 2018/9/1

N2 - The mandate of folic acid supplementation in grained products has reduced the occurrence of neural tube defects by one third in the U.S since its introduction by the Food and Drug Administration in 1998. However, the advantages and possible mechanisms of action of using folic acid for peripheral nerve engineering and neurological diseases still remain largely elusive. Herein, folic acid is described as an inexpensive and multifunctional niche component that modulates behaviors in different cells in the nervous system. The multiple benefits of modulation include: 1) generating chemotactic responses on glial cells, 2) inducing neurotrophin release, and 3) stimulating neuronal differentiation of a PC-12 cell system. For the first time, folic acid is also shown to enhance cellular force generation and global methylation in the PC-12 cells, thereby enabling both biomechanical and biochemical pathways to regulate neuron differentiation. These findings are evaluated in vivo for clinical translation. Our results suggest that folic acid-nerve guidance conduits may offer significant benefits as a low-cost, off-the-shelf product for reaching the functional recovery seen with autografts in large sciatic nerve defects. Consequently, folic acid holds great potential as a critical and convenient therapeutic intervention for neural engineering, regenerative medicine, medical prosthetics, and drug delivery.

AB - The mandate of folic acid supplementation in grained products has reduced the occurrence of neural tube defects by one third in the U.S since its introduction by the Food and Drug Administration in 1998. However, the advantages and possible mechanisms of action of using folic acid for peripheral nerve engineering and neurological diseases still remain largely elusive. Herein, folic acid is described as an inexpensive and multifunctional niche component that modulates behaviors in different cells in the nervous system. The multiple benefits of modulation include: 1) generating chemotactic responses on glial cells, 2) inducing neurotrophin release, and 3) stimulating neuronal differentiation of a PC-12 cell system. For the first time, folic acid is also shown to enhance cellular force generation and global methylation in the PC-12 cells, thereby enabling both biomechanical and biochemical pathways to regulate neuron differentiation. These findings are evaluated in vivo for clinical translation. Our results suggest that folic acid-nerve guidance conduits may offer significant benefits as a low-cost, off-the-shelf product for reaching the functional recovery seen with autografts in large sciatic nerve defects. Consequently, folic acid holds great potential as a critical and convenient therapeutic intervention for neural engineering, regenerative medicine, medical prosthetics, and drug delivery.

UR - http://www.scopus.com/inward/record.url?scp=85053215785&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053215785&partnerID=8YFLogxK

U2 - 10.1016/j.biomaterials.2018.03.059

DO - 10.1016/j.biomaterials.2018.03.059

M3 - Article

C2 - 29657092

AN - SCOPUS:85053215785

VL - 178

SP - 504

EP - 516

JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

ER -