The development and function of follicular helper T cells in immune responses

Maogen Chen, Zhiyong Guo, Weiqiang Ju, Bernhard Ryffel, Xiaoshun He, Song Guo Zheng

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

Follicular helper T cells (Tfh) have been referred as a lineage that provides a help for B cells to proliferate and undergo antibody affinity maturation in the germinal center. Evidence has supported that Tfh subset development, like other lineages, is dependent on microenvironment where a particular transcriptional program is initiated. It has been shown that Bcl-6 and IL-21 act as master regulators for the development and function of Tfh cells. Tfh dysregulation is involved in the development of autoimmune pathologies, such as systemic lupus erythematosus, rheumatoid arthritis and other autoimmune diseases. The present review highlights the recent advances in the field of Tfh cells and focus on their development and function.

Original languageEnglish (US)
Pages (from-to)375-379
Number of pages5
JournalCellular and Molecular Immunology
Volume9
Issue number5
DOIs
StatePublished - Sep 2012

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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