The development of catalytic nucleophilic substitution reactions: Challenges, progress and future directions

Jie An, Ross M. Denton, Tristan H. Lambert, Eric Nacsa

Research output: Contribution to journalReview article

57 Scopus citations


Bimolecular nucleophilic substitution reactions of alcohols are fundamentally important transformations in organic chemistry yet, to date, they are relatively underdeveloped with respect to catalysis. This Article describes the emerging area of catalytic SN2 reactions with specific emphasis on the design and development of phosphorus(v) and cyclopropenone-based catalytic SN2 reactions of alcohols.

Original languageEnglish (US)
Pages (from-to)2993-3003
Number of pages11
JournalOrganic and Biomolecular Chemistry
Issue number19
Publication statusPublished - May 21 2014


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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