The development of novel and selective p56(lck) tyrosine kinase inhibitors

James L. Bullington, Julie C. Cameron, Janet E. Davis, John H. Dodd, Crafford A. Harris, James R. Henry, J. Lee Pellegrino-Gensey, Kenneth C. Rupert, John J. Siekierka

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Early T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56(lck), is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Indandiones have been identified as a potent and selective chemical class that inhibits p56(lck).

Original languageEnglish (US)
Pages (from-to)2489-2494
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number18
DOIs
StatePublished - Sep 22 1998

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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