TY - JOUR
T1 - The dissociation of anterograde and retrograde amnesia in a patient with herpes encephalitis
AU - O'Connor, M.
AU - Butters, N.
AU - Miliotis, P.
AU - Eslinger, P.
AU - Cermak, L. S.
N1 - Funding Information:
Anterograde amnesia (AA) and retrograde amnesia (RA) are both well acknowledged features of the amnesic syndrome, but the precise relationship between these two forms of memory loss in individual patients remains a point of much debate. Squire (1987) has proposed that AA and RA are highly correlated in that density of AA usually predicts density of RA for any given patient. Kopleman, Wilson, and Baddeley (1989), on the other hand, report no significant relationship between the severity of AA and RA. The resolution of this disparity is exceedingly important to investigators of the amnesic syndrome. If AA and RA * This report is funded in part by NINCDS program project grant NS 26985, funds from the Department of Veterans Affairs Medical Research Service, and by NIAAA grant AA-00187. The authors express their appreciation to Drs. Antonio and Hanna Damasio for providing the MR report cited in this paper. Address correspondence and reprint requests to Margaret O'Connor, Psychology Service (1 16B). Department of Veterans Affairs Medical Center, 150 S.H untington Ave., Boston, MA 02130, USA. Accepted for publication: April 3, 1991.
PY - 1992
Y1 - 1992
N2 - Establishing the precise relationship between anterograde amnesia (AA) and retrograde amnesia (RA) has implications for psychological and neuroanatomical models of memory. Many patients have been described who demonstrate AA inconjunction with RA or who demonstrate AA with little, or no apparent, RA. Intact anterograde memory in conjunction with deficits on tasks of retrograde memory is rarely encountered. In this paper, we describe a young female patient (LD) whose RA is extremely severe when contrasted with her mild to moderate deficits on tasks of verbal anterograde memory. In addition, on tests of episodic and semantic autobiographical memory, LD appeared more impaired in her recall of specific episodes than of factual information about her past. The importance of this dissociation in RA for the episodic-semantic distinction and the possible role of visual imagery in recalling remote episodic events are discussed.
AB - Establishing the precise relationship between anterograde amnesia (AA) and retrograde amnesia (RA) has implications for psychological and neuroanatomical models of memory. Many patients have been described who demonstrate AA inconjunction with RA or who demonstrate AA with little, or no apparent, RA. Intact anterograde memory in conjunction with deficits on tasks of retrograde memory is rarely encountered. In this paper, we describe a young female patient (LD) whose RA is extremely severe when contrasted with her mild to moderate deficits on tasks of verbal anterograde memory. In addition, on tests of episodic and semantic autobiographical memory, LD appeared more impaired in her recall of specific episodes than of factual information about her past. The importance of this dissociation in RA for the episodic-semantic distinction and the possible role of visual imagery in recalling remote episodic events are discussed.
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U2 - 10.1080/01688639208402821
DO - 10.1080/01688639208402821
M3 - Article
C2 - 1572943
AN - SCOPUS:0026597105
SN - 0168-8634
VL - 14
SP - 159
EP - 178
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
IS - 2
ER -