The diverse contributions of fucose linkages in cancer

Tyler S. Keeley, Shengyu Yang, Eric Lau

Research output: Contribution to journalArticle

Abstract

Fucosylation is a post-translational modification of glycans, proteins, and lipids that is responsible for many biological processes. Fucose conjugation via α(1,2), α(1,3), α(1,4), α(1,6), and O’- linkages to glycans, and variations in fucosylation linkages, has important implications for cancer biology. This review focuses on the roles that fucosylation plays in cancer, specifically through modulation of cell surface proteins and signaling pathways. How L-fucose and serum fucosylation patterns might be used for future clinical diagnostic, prognostic, and therapeutic approaches will be discussed.

Original languageEnglish (US)
Article number1241
JournalCancers
Volume11
Issue number9
DOIs
StatePublished - Sep 1 2019

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Fucose
Polysaccharides
Biological Phenomena
Post Translational Protein Processing
Neoplasms
Membrane Proteins
Lipids
Serum
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Keeley, Tyler S. ; Yang, Shengyu ; Lau, Eric. / The diverse contributions of fucose linkages in cancer. In: Cancers. 2019 ; Vol. 11, No. 9.
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The diverse contributions of fucose linkages in cancer. / Keeley, Tyler S.; Yang, Shengyu; Lau, Eric.

In: Cancers, Vol. 11, No. 9, 1241, 01.09.2019.

Research output: Contribution to journalArticle

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