The diversity of health effects of individual trans fatty acid isomers

Sarah K. Gebauer, Tricia L. Psota, Penny Margaret Kris-Etherton

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

There are multiple adverse effects of trans fatty acids (TFA) that are produced by partial hydrogenation (i.e., manufactured TFA), on CVD, blood lipids, inflammation, oxidative stress, endothelial health, body weight, insulin sensitivity, and cancer. It is not yet clear how specific TFA isomers vary in their biological activity and mechanisms of action. There is evidence of health benefits on some of the endpoints that have been studied for some animal TFA isomers, such as conjugated linoleic acid; however, these are not a major TFA source in the diet. Future research will bring clarity to our understanding of the biological effects of the individual TFA isomers. At this point, it is not possible to plan diets that emphasize individual TFA from animal sources at levels that would be expected to have significant health effects. Due to the multiple adverse effects of manufactured TFA, numerous agencies and governing bodies recommend limiting TFA in the diet and reducing TFA in the food supply. These initiatives and regulations, along with potential TFA alternatives, are presented herein.

Original languageEnglish (US)
Pages (from-to)787-799
Number of pages13
JournalLipids
Volume42
Issue number9
DOIs
StatePublished - Sep 1 2007

Fingerprint

Trans Fatty Acids
Isomers
Health
Nutrition
Animals
Food supply
Reducing Diet
Diet
Conjugated Linoleic Acids
Oxidative stress
Hydrogenation
Food Supply
Insurance Benefits
Bioactivity
Insulin Resistance
Chemical vapor deposition
Oxidative Stress
Blood

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

Cite this

Gebauer, Sarah K. ; Psota, Tricia L. ; Kris-Etherton, Penny Margaret. / The diversity of health effects of individual trans fatty acid isomers. In: Lipids. 2007 ; Vol. 42, No. 9. pp. 787-799.
@article{11e8b9924c754308ba19f05580093a68,
title = "The diversity of health effects of individual trans fatty acid isomers",
abstract = "There are multiple adverse effects of trans fatty acids (TFA) that are produced by partial hydrogenation (i.e., manufactured TFA), on CVD, blood lipids, inflammation, oxidative stress, endothelial health, body weight, insulin sensitivity, and cancer. It is not yet clear how specific TFA isomers vary in their biological activity and mechanisms of action. There is evidence of health benefits on some of the endpoints that have been studied for some animal TFA isomers, such as conjugated linoleic acid; however, these are not a major TFA source in the diet. Future research will bring clarity to our understanding of the biological effects of the individual TFA isomers. At this point, it is not possible to plan diets that emphasize individual TFA from animal sources at levels that would be expected to have significant health effects. Due to the multiple adverse effects of manufactured TFA, numerous agencies and governing bodies recommend limiting TFA in the diet and reducing TFA in the food supply. These initiatives and regulations, along with potential TFA alternatives, are presented herein.",
author = "Gebauer, {Sarah K.} and Psota, {Tricia L.} and Kris-Etherton, {Penny Margaret}",
year = "2007",
month = "9",
day = "1",
doi = "10.1007/s11745-007-3095-8",
language = "English (US)",
volume = "42",
pages = "787--799",
journal = "Lipids",
issn = "0024-4201",
publisher = "Springer Verlag",
number = "9",

}

The diversity of health effects of individual trans fatty acid isomers. / Gebauer, Sarah K.; Psota, Tricia L.; Kris-Etherton, Penny Margaret.

In: Lipids, Vol. 42, No. 9, 01.09.2007, p. 787-799.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The diversity of health effects of individual trans fatty acid isomers

AU - Gebauer, Sarah K.

AU - Psota, Tricia L.

AU - Kris-Etherton, Penny Margaret

PY - 2007/9/1

Y1 - 2007/9/1

N2 - There are multiple adverse effects of trans fatty acids (TFA) that are produced by partial hydrogenation (i.e., manufactured TFA), on CVD, blood lipids, inflammation, oxidative stress, endothelial health, body weight, insulin sensitivity, and cancer. It is not yet clear how specific TFA isomers vary in their biological activity and mechanisms of action. There is evidence of health benefits on some of the endpoints that have been studied for some animal TFA isomers, such as conjugated linoleic acid; however, these are not a major TFA source in the diet. Future research will bring clarity to our understanding of the biological effects of the individual TFA isomers. At this point, it is not possible to plan diets that emphasize individual TFA from animal sources at levels that would be expected to have significant health effects. Due to the multiple adverse effects of manufactured TFA, numerous agencies and governing bodies recommend limiting TFA in the diet and reducing TFA in the food supply. These initiatives and regulations, along with potential TFA alternatives, are presented herein.

AB - There are multiple adverse effects of trans fatty acids (TFA) that are produced by partial hydrogenation (i.e., manufactured TFA), on CVD, blood lipids, inflammation, oxidative stress, endothelial health, body weight, insulin sensitivity, and cancer. It is not yet clear how specific TFA isomers vary in their biological activity and mechanisms of action. There is evidence of health benefits on some of the endpoints that have been studied for some animal TFA isomers, such as conjugated linoleic acid; however, these are not a major TFA source in the diet. Future research will bring clarity to our understanding of the biological effects of the individual TFA isomers. At this point, it is not possible to plan diets that emphasize individual TFA from animal sources at levels that would be expected to have significant health effects. Due to the multiple adverse effects of manufactured TFA, numerous agencies and governing bodies recommend limiting TFA in the diet and reducing TFA in the food supply. These initiatives and regulations, along with potential TFA alternatives, are presented herein.

UR - http://www.scopus.com/inward/record.url?scp=35348895600&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35348895600&partnerID=8YFLogxK

U2 - 10.1007/s11745-007-3095-8

DO - 10.1007/s11745-007-3095-8

M3 - Article

C2 - 17694343

AN - SCOPUS:35348895600

VL - 42

SP - 787

EP - 799

JO - Lipids

JF - Lipids

SN - 0024-4201

IS - 9

ER -