The dose-response effects of aerobic exercise on body composition and breast tissue among women at high risk for breast cancer: A randomized trial

Justin C. Brown, Despina Kontos, Mitchell D. Schnall, Shandong Wu, Kathryn H. Schmitz

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Observational data indicate that behaviors that shift energetic homeostasis, such as exercise, may decrease the risk of developing breast cancer by reducing the amount of energydense, metabolically active adipose tissue. Between December 2008 and April 2013, we conducted a single-blind, 5-month, clinical trial that randomized premenopausal women at high risk of developing breast cancer to one of three groups: 150 min/wk of aerobic exercise (low dose), 300 min/wk of aerobic exercise (high dose), or control. Body composition was assessed using dual-energy x-ray absorptiometry. Background parenchymal enhancement (BPE) was quantified using computerized algorithms on breast dynamic contrast-enhanced MRI. Over 5 months, compared with the control group: the low-dose and high-dose groups lost -1.5 ± 0.5 and -1.3 ± 0.5 kg of body mass (linear Ptrend = 0.032); -1.5 ± 0.4 and -1.4 ±0.3 kg of fat mass (linear Ptrend =0.003); -1.3 ±0.3 and -1.4 ± 0.3% of body fat (linear Ptrend < 0.001); -15.9 ± 5.4 and -26.6 ± 5.0 cm2 of subcutaneous adipose tissue (linear Ptrend < 0.001); and -6.6 ± 1.9 and -5.0 ± 1.9 cm2 visceral adipose tissue (nonlinear Ptrend = 0.037). For each -1 cm2 reduction in visceral adipose tissue, BPE decreased by -3.43 ± 1.34 cm2 (P = 0.010) and explained 9.7% of the variability in BPE. Changes in other aforementioned body composition outcomes did not significantly correlate with changes in BPE. These mechanistic data support observational evidence that shifting energetic homeostasis through exercise may alter the risk of developing breast cancer. Additional adequately powered studies are needed to confirm and expand upon our findings that changes in body composition are associated with changes in BPE.

Original languageEnglish (US)
Pages (from-to)581-588
Number of pages8
JournalCancer Prevention Research
Volume9
Issue number7
DOIs
StatePublished - Jul 2016

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Body Composition
Breast
Exercise
Breast Neoplasms
Intra-Abdominal Fat
Adipose Tissue
Homeostasis
Subcutaneous Fat
Randomized Controlled Trials
Fats
X-Rays
Control Groups

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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title = "The dose-response effects of aerobic exercise on body composition and breast tissue among women at high risk for breast cancer: A randomized trial",
abstract = "Observational data indicate that behaviors that shift energetic homeostasis, such as exercise, may decrease the risk of developing breast cancer by reducing the amount of energydense, metabolically active adipose tissue. Between December 2008 and April 2013, we conducted a single-blind, 5-month, clinical trial that randomized premenopausal women at high risk of developing breast cancer to one of three groups: 150 min/wk of aerobic exercise (low dose), 300 min/wk of aerobic exercise (high dose), or control. Body composition was assessed using dual-energy x-ray absorptiometry. Background parenchymal enhancement (BPE) was quantified using computerized algorithms on breast dynamic contrast-enhanced MRI. Over 5 months, compared with the control group: the low-dose and high-dose groups lost -1.5 ± 0.5 and -1.3 ± 0.5 kg of body mass (linear Ptrend = 0.032); -1.5 ± 0.4 and -1.4 ±0.3 kg of fat mass (linear Ptrend =0.003); -1.3 ±0.3 and -1.4 ± 0.3{\%} of body fat (linear Ptrend < 0.001); -15.9 ± 5.4 and -26.6 ± 5.0 cm2 of subcutaneous adipose tissue (linear Ptrend < 0.001); and -6.6 ± 1.9 and -5.0 ± 1.9 cm2 visceral adipose tissue (nonlinear Ptrend = 0.037). For each -1 cm2 reduction in visceral adipose tissue, BPE decreased by -3.43 ± 1.34 cm2 (P = 0.010) and explained 9.7{\%} of the variability in BPE. Changes in other aforementioned body composition outcomes did not significantly correlate with changes in BPE. These mechanistic data support observational evidence that shifting energetic homeostasis through exercise may alter the risk of developing breast cancer. Additional adequately powered studies are needed to confirm and expand upon our findings that changes in body composition are associated with changes in BPE.",
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The dose-response effects of aerobic exercise on body composition and breast tissue among women at high risk for breast cancer : A randomized trial. / Brown, Justin C.; Kontos, Despina; Schnall, Mitchell D.; Wu, Shandong; Schmitz, Kathryn H.

In: Cancer Prevention Research, Vol. 9, No. 7, 07.2016, p. 581-588.

Research output: Contribution to journalArticle

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