The double-stranded-RNA-binding motif: Interference and much more

Bin Tian, Philip C. Bevilacqua, Amy Diegelman-Parente, Michael B. Mathews

Research output: Contribution to journalReview article

173 Scopus citations


RNA duplexes have been catapulted into the spotlight by the discovery of RNA interference and related phenomena. But double-stranded and highly structured RNAs have long been recognized as key players in cell processes ranging from RNA maturation and localization to the antiviral response in higher organisms. Penetrating insights into the metabolism and functions of such RNAs have come from the identification and study of proteins that contain the double-stranded-RNA-binding motif.

Original languageEnglish (US)
Pages (from-to)1013-1023
Number of pages11
JournalNature Reviews Molecular Cell Biology
Issue number12
Publication statusPublished - Dec 1 2004


All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this