The Drosophila ortholog of breast cancer metastasis suppressor gene, dBrms1, is critical for developmental timing through regulating ecdysone signaling

Shilin Song, Yuan Yuan, Jinfeng Lu, Qi Li, Zuoyan Zhu, Qichang Fan, Youfang Xue, Zhi Chun Lai, Wenxia Zhang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

BRMS1 was first discovered as a human breast carcinoma metastasis suppressor gene. However, the mechanism of BRMS1 in tumor metastasis and its developmental role remain unclear. In this paper, we first report the identification of the Drosophila ortholog of human BRMS1, dBrms1. Through a genetic approach, the role of dBrms1 during development has been investigated. We found that dBrms1 is an essential gene and loss of dBrms1 function results in lethality at early developmental stages. dBrms1mutants displayed phenotypes such as developmental delay and failure to initiate metamorphosis. Further analysis suggests that these phenotypes are contributed by defective ecdysone signaling and expression of target genes of the ecdysone pathway. Therefore, dBrms1 is required for growth control by acting as a modulator of ecdysone signaling in Drosophila and is required for metamorphosis for normal development.

Original languageEnglish (US)
Pages (from-to)344-350
Number of pages7
JournalDevelopmental biology
Volume380
Issue number2
DOIs
StatePublished - Aug 15 2013

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'The Drosophila ortholog of breast cancer metastasis suppressor gene, dBrms1, is critical for developmental timing through regulating ecdysone signaling'. Together they form a unique fingerprint.

Cite this