The DXS423E gene in XP11.21 escapes X chromosome inactivation

Carolyn J. Brown, Andrew P. Miller, Laura Carrel, Jim L. Rupert, Kay E. Davies, Huntington F. Willard

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The DXS423E gene has been localized to Xp11.21 and is expressed in somatic cell hybrids retaining either the human active or inactive X chromosome, demonstrating that DXS423E escapes X chromosome inactivation. The XE169 (DXS1272E or SMCX) gene that escapes X chromosome Inactivation is also located in Xp11.21-11.22 and maps within the same YAC as DXS423E. Thus the DXS423E and XE169 genes define a new region in the proximal short arm of the X chromosome that is not subject to X chromosome inactivation, supporting a regional basis for escape from inactivation.

Original languageEnglish (US)
Pages (from-to)251-255
Number of pages5
JournalHuman Molecular Genetics
Volume4
Issue number2
DOIs
StatePublished - Feb 1 1995

Fingerprint

X Chromosome Inactivation
X Chromosome
Genes
Hybrid Cells

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Brown, C. J., Miller, A. P., Carrel, L., Rupert, J. L., Davies, K. E., & Willard, H. F. (1995). The DXS423E gene in XP11.21 escapes X chromosome inactivation. Human Molecular Genetics, 4(2), 251-255. https://doi.org/10.1093/hmg/4.2.251
Brown, Carolyn J. ; Miller, Andrew P. ; Carrel, Laura ; Rupert, Jim L. ; Davies, Kay E. ; Willard, Huntington F. / The DXS423E gene in XP11.21 escapes X chromosome inactivation. In: Human Molecular Genetics. 1995 ; Vol. 4, No. 2. pp. 251-255.
@article{fc80a57593a948d0b9c92396ef0a5554,
title = "The DXS423E gene in XP11.21 escapes X chromosome inactivation",
abstract = "The DXS423E gene has been localized to Xp11.21 and is expressed in somatic cell hybrids retaining either the human active or inactive X chromosome, demonstrating that DXS423E escapes X chromosome inactivation. The XE169 (DXS1272E or SMCX) gene that escapes X chromosome Inactivation is also located in Xp11.21-11.22 and maps within the same YAC as DXS423E. Thus the DXS423E and XE169 genes define a new region in the proximal short arm of the X chromosome that is not subject to X chromosome inactivation, supporting a regional basis for escape from inactivation.",
author = "Brown, {Carolyn J.} and Miller, {Andrew P.} and Laura Carrel and Rupert, {Jim L.} and Davies, {Kay E.} and Willard, {Huntington F.}",
year = "1995",
month = "2",
day = "1",
doi = "10.1093/hmg/4.2.251",
language = "English (US)",
volume = "4",
pages = "251--255",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "2",

}

Brown, CJ, Miller, AP, Carrel, L, Rupert, JL, Davies, KE & Willard, HF 1995, 'The DXS423E gene in XP11.21 escapes X chromosome inactivation', Human Molecular Genetics, vol. 4, no. 2, pp. 251-255. https://doi.org/10.1093/hmg/4.2.251

The DXS423E gene in XP11.21 escapes X chromosome inactivation. / Brown, Carolyn J.; Miller, Andrew P.; Carrel, Laura; Rupert, Jim L.; Davies, Kay E.; Willard, Huntington F.

In: Human Molecular Genetics, Vol. 4, No. 2, 01.02.1995, p. 251-255.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The DXS423E gene in XP11.21 escapes X chromosome inactivation

AU - Brown, Carolyn J.

AU - Miller, Andrew P.

AU - Carrel, Laura

AU - Rupert, Jim L.

AU - Davies, Kay E.

AU - Willard, Huntington F.

PY - 1995/2/1

Y1 - 1995/2/1

N2 - The DXS423E gene has been localized to Xp11.21 and is expressed in somatic cell hybrids retaining either the human active or inactive X chromosome, demonstrating that DXS423E escapes X chromosome inactivation. The XE169 (DXS1272E or SMCX) gene that escapes X chromosome Inactivation is also located in Xp11.21-11.22 and maps within the same YAC as DXS423E. Thus the DXS423E and XE169 genes define a new region in the proximal short arm of the X chromosome that is not subject to X chromosome inactivation, supporting a regional basis for escape from inactivation.

AB - The DXS423E gene has been localized to Xp11.21 and is expressed in somatic cell hybrids retaining either the human active or inactive X chromosome, demonstrating that DXS423E escapes X chromosome inactivation. The XE169 (DXS1272E or SMCX) gene that escapes X chromosome Inactivation is also located in Xp11.21-11.22 and maps within the same YAC as DXS423E. Thus the DXS423E and XE169 genes define a new region in the proximal short arm of the X chromosome that is not subject to X chromosome inactivation, supporting a regional basis for escape from inactivation.

UR - http://www.scopus.com/inward/record.url?scp=0028950973&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028950973&partnerID=8YFLogxK

U2 - 10.1093/hmg/4.2.251

DO - 10.1093/hmg/4.2.251

M3 - Article

VL - 4

SP - 251

EP - 255

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 2

ER -