The DXS423E gene in XP11.21 escapes X chromosome inactivation

Carolyn J. Brown, Andrew P. Miller, Laura Carrel, Jim L. Rupert, Kay E. Davies, Huntington F. Willard

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The DXS423E gene has been localized to Xp11.21 and is expressed in somatic cell hybrids retaining either the human active or inactive X chromosome, demonstrating that DXS423E escapes X chromosome inactivation. The XE169 (DXS1272E or SMCX) gene that escapes X chromosome Inactivation is also located in Xp11.21-11.22 and maps within the same YAC as DXS423E. Thus the DXS423E and XE169 genes define a new region in the proximal short arm of the X chromosome that is not subject to X chromosome inactivation, supporting a regional basis for escape from inactivation.

Original languageEnglish (US)
Pages (from-to)251-255
Number of pages5
JournalHuman molecular genetics
Volume4
Issue number2
DOIs
StatePublished - Feb 1 1995

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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