The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam

Phan Vu Tra My, Ha Minh Lam, Corinne N. Thompson, Hoang Le Phuc, Pham Thi Ngoc Tuyet, Ha Vinh, Nguyen Van Minh Hoang, Pham Van Minh, Nguyen Thanh Vinh, Cao Thu Thuy, Tran Thi Thu Nga, Nguyen Thi Thu Hau, Nguyen Tran Chinh, Tang Chi Thuong, Ha Manh Tuan, James I. Campbell, Archie C.A. Clements, Jeremy Farrar, Maciej F. Boni, Stephen Baker

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Norovirus (NoV) is a major cause of epidemic gastroenteritis in industrialized countries, yet the epidemiological significance of NoV in industrializing countries remains poorly understood. The spatiotemporal distribution of NoV genotypes identified in 2054 enrolled children was investigated between May 2009 and December 2010, in Ho Chi Minh City (HCMC), Vietnam. A total of 315 NoV extracted from stool samples were genotyped and GPS mapped to their source. Genogroup II NoV, particularly GII.4, were predominant, and the GII.4 strains could be subgrouped into GII.4-2006b (Minerva) and GII.4-2010 (New Orleans) variants. There was no spatiotemporal structure among the endemic GII strains; yet a significant spatiotemporal signal corresponding with the novel introduction of GII.4-2010 variant was detected. These data show that NoV GII.4 variants are highly endemic in HCMC and describe a scenario of rapid NoV strain replacement occurring in HCMC in early 2010.

Original languageEnglish (US)
Pages (from-to)335-343
Number of pages9
JournalInfection, Genetics and Evolution
Volume18
DOIs
StatePublished - Jul 23 2013

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Norovirus
Vietnam
gastroenteritis
genotype
GPS
replacement
Genotype
Gastroenteritis
city
Developed Countries
developed countries

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Tra My, P. V., Lam, H. M., Thompson, C. N., Phuc, H. L., Tuyet, P. T. N., Vinh, H., ... Baker, S. (2013). The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam. Infection, Genetics and Evolution, 18, 335-343. https://doi.org/10.1016/j.meegid.2013.04.014
Tra My, Phan Vu ; Lam, Ha Minh ; Thompson, Corinne N. ; Phuc, Hoang Le ; Tuyet, Pham Thi Ngoc ; Vinh, Ha ; Hoang, Nguyen Van Minh ; Minh, Pham Van ; Vinh, Nguyen Thanh ; Thuy, Cao Thu ; Nga, Tran Thi Thu ; Hau, Nguyen Thi Thu ; Chinh, Nguyen Tran ; Thuong, Tang Chi ; Tuan, Ha Manh ; Campbell, James I. ; Clements, Archie C.A. ; Farrar, Jeremy ; Boni, Maciej F. ; Baker, Stephen. / The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam. In: Infection, Genetics and Evolution. 2013 ; Vol. 18. pp. 335-343.
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abstract = "Norovirus (NoV) is a major cause of epidemic gastroenteritis in industrialized countries, yet the epidemiological significance of NoV in industrializing countries remains poorly understood. The spatiotemporal distribution of NoV genotypes identified in 2054 enrolled children was investigated between May 2009 and December 2010, in Ho Chi Minh City (HCMC), Vietnam. A total of 315 NoV extracted from stool samples were genotyped and GPS mapped to their source. Genogroup II NoV, particularly GII.4, were predominant, and the GII.4 strains could be subgrouped into GII.4-2006b (Minerva) and GII.4-2010 (New Orleans) variants. There was no spatiotemporal structure among the endemic GII strains; yet a significant spatiotemporal signal corresponding with the novel introduction of GII.4-2010 variant was detected. These data show that NoV GII.4 variants are highly endemic in HCMC and describe a scenario of rapid NoV strain replacement occurring in HCMC in early 2010.",
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Tra My, PV, Lam, HM, Thompson, CN, Phuc, HL, Tuyet, PTN, Vinh, H, Hoang, NVM, Minh, PV, Vinh, NT, Thuy, CT, Nga, TTT, Hau, NTT, Chinh, NT, Thuong, TC, Tuan, HM, Campbell, JI, Clements, ACA, Farrar, J, Boni, MF & Baker, S 2013, 'The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam', Infection, Genetics and Evolution, vol. 18, pp. 335-343. https://doi.org/10.1016/j.meegid.2013.04.014

The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam. / Tra My, Phan Vu; Lam, Ha Minh; Thompson, Corinne N.; Phuc, Hoang Le; Tuyet, Pham Thi Ngoc; Vinh, Ha; Hoang, Nguyen Van Minh; Minh, Pham Van; Vinh, Nguyen Thanh; Thuy, Cao Thu; Nga, Tran Thi Thu; Hau, Nguyen Thi Thu; Chinh, Nguyen Tran; Thuong, Tang Chi; Tuan, Ha Manh; Campbell, James I.; Clements, Archie C.A.; Farrar, Jeremy; Boni, Maciej F.; Baker, Stephen.

In: Infection, Genetics and Evolution, Vol. 18, 23.07.2013, p. 335-343.

Research output: Contribution to journalArticle

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T1 - The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam

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AU - Phuc, Hoang Le

AU - Tuyet, Pham Thi Ngoc

AU - Vinh, Ha

AU - Hoang, Nguyen Van Minh

AU - Minh, Pham Van

AU - Vinh, Nguyen Thanh

AU - Thuy, Cao Thu

AU - Nga, Tran Thi Thu

AU - Hau, Nguyen Thi Thu

AU - Chinh, Nguyen Tran

AU - Thuong, Tang Chi

AU - Tuan, Ha Manh

AU - Campbell, James I.

AU - Clements, Archie C.A.

AU - Farrar, Jeremy

AU - Boni, Maciej F.

AU - Baker, Stephen

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Tra My PV, Lam HM, Thompson CN, Phuc HL, Tuyet PTN, Vinh H et al. The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam. Infection, Genetics and Evolution. 2013 Jul 23;18:335-343. https://doi.org/10.1016/j.meegid.2013.04.014