Abstract
Norovirus (NoV) is a major cause of epidemic gastroenteritis in industrialized countries, yet the epidemiological significance of NoV in industrializing countries remains poorly understood. The spatiotemporal distribution of NoV genotypes identified in 2054 enrolled children was investigated between May 2009 and December 2010, in Ho Chi Minh City (HCMC), Vietnam. A total of 315 NoV extracted from stool samples were genotyped and GPS mapped to their source. Genogroup II NoV, particularly GII.4, were predominant, and the GII.4 strains could be subgrouped into GII.4-2006b (Minerva) and GII.4-2010 (New Orleans) variants. There was no spatiotemporal structure among the endemic GII strains; yet a significant spatiotemporal signal corresponding with the novel introduction of GII.4-2010 variant was detected. These data show that NoV GII.4 variants are highly endemic in HCMC and describe a scenario of rapid NoV strain replacement occurring in HCMC in early 2010.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 335-343 |
| Number of pages | 9 |
| Journal | Infection, Genetics and Evolution |
| Volume | 18 |
| DOIs | |
| State | Published - Jul 23 2013 |
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All Science Journal Classification (ASJC) codes
- Microbiology
- Ecology, Evolution, Behavior and Systematics
- Molecular Biology
- Genetics
- Microbiology (medical)
- Infectious Diseases
Cite this
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The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam. / Tra My, Phan Vu; Lam, Ha Minh; Thompson, Corinne N.; Phuc, Hoang Le; Tuyet, Pham Thi Ngoc; Vinh, Ha; Hoang, Nguyen Van Minh; Minh, Pham Van; Vinh, Nguyen Thanh; Thuy, Cao Thu; Nga, Tran Thi Thu; Hau, Nguyen Thi Thu; Chinh, Nguyen Tran; Thuong, Tang Chi; Tuan, Ha Manh; Campbell, James I.; Clements, Archie C.A.; Farrar, Jeremy; Boni, Maciej F.; Baker, Stephen.
In: Infection, Genetics and Evolution, Vol. 18, 23.07.2013, p. 335-343.Research output: Contribution to journal › Article
TY - JOUR
T1 - The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam
AU - Tra My, Phan Vu
AU - Lam, Ha Minh
AU - Thompson, Corinne N.
AU - Phuc, Hoang Le
AU - Tuyet, Pham Thi Ngoc
AU - Vinh, Ha
AU - Hoang, Nguyen Van Minh
AU - Minh, Pham Van
AU - Vinh, Nguyen Thanh
AU - Thuy, Cao Thu
AU - Nga, Tran Thi Thu
AU - Hau, Nguyen Thi Thu
AU - Chinh, Nguyen Tran
AU - Thuong, Tang Chi
AU - Tuan, Ha Manh
AU - Campbell, James I.
AU - Clements, Archie C.A.
AU - Farrar, Jeremy
AU - Boni, Maciej F.
AU - Baker, Stephen
PY - 2013/7/23
Y1 - 2013/7/23
N2 - Norovirus (NoV) is a major cause of epidemic gastroenteritis in industrialized countries, yet the epidemiological significance of NoV in industrializing countries remains poorly understood. The spatiotemporal distribution of NoV genotypes identified in 2054 enrolled children was investigated between May 2009 and December 2010, in Ho Chi Minh City (HCMC), Vietnam. A total of 315 NoV extracted from stool samples were genotyped and GPS mapped to their source. Genogroup II NoV, particularly GII.4, were predominant, and the GII.4 strains could be subgrouped into GII.4-2006b (Minerva) and GII.4-2010 (New Orleans) variants. There was no spatiotemporal structure among the endemic GII strains; yet a significant spatiotemporal signal corresponding with the novel introduction of GII.4-2010 variant was detected. These data show that NoV GII.4 variants are highly endemic in HCMC and describe a scenario of rapid NoV strain replacement occurring in HCMC in early 2010.
AB - Norovirus (NoV) is a major cause of epidemic gastroenteritis in industrialized countries, yet the epidemiological significance of NoV in industrializing countries remains poorly understood. The spatiotemporal distribution of NoV genotypes identified in 2054 enrolled children was investigated between May 2009 and December 2010, in Ho Chi Minh City (HCMC), Vietnam. A total of 315 NoV extracted from stool samples were genotyped and GPS mapped to their source. Genogroup II NoV, particularly GII.4, were predominant, and the GII.4 strains could be subgrouped into GII.4-2006b (Minerva) and GII.4-2010 (New Orleans) variants. There was no spatiotemporal structure among the endemic GII strains; yet a significant spatiotemporal signal corresponding with the novel introduction of GII.4-2010 variant was detected. These data show that NoV GII.4 variants are highly endemic in HCMC and describe a scenario of rapid NoV strain replacement occurring in HCMC in early 2010.
UR - http://www.scopus.com/inward/record.url?scp=84880305870&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880305870&partnerID=8YFLogxK
U2 - 10.1016/j.meegid.2013.04.014
DO - 10.1016/j.meegid.2013.04.014
M3 - Article
C2 - 23612321
AN - SCOPUS:84880305870
VL - 18
SP - 335
EP - 343
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
SN - 1567-1348
ER -