The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer

Vanja Stojković, Laura L. Perissinotti, Jeeyeon Lee, Stephen J. Benkovic, Amnon Kohen

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Comparison of the nature of hydride transfer in wild-type and active site mutant (I14A) of dihydrofolate reductase suggests that the size of this side chain at position 14 modulates H-tunneling.

Original languageEnglish (US)
Pages (from-to)8974-8976
Number of pages3
JournalChemical Communications
Volume46
Issue number47
DOIs
StatePublished - Dec 21 2010

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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