The Effect of Adrenalectomy on the Restraint Stressed Induced Suppression of MHC Class II Expression by Murine Peritoneal Macrophages

Bruce S. Zwilling, David Brown, Ningguo G. Feng, John Sheridan, Dennis Keith Pearl

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Restraint stress suppresses the expression of MHC class II (I-A) glycoproteins by murine peritoneal macrophages. In order to evaluate the role of the pituitary adrenal axis, the effect of restraint stress on I-A expression by macrophages from adrenalectomized mice was evaluated. Adrenalectomy resulted in elevated levels of ACTH but abrogated the increase in corticosterone that results from restraint stress. The expression of I-A by macrophages from adrenalectomized mice was similar to that of sham operated mice or untreated mice. Adrenalectomy ameliorated the suppressive effects of restraint but the expression of I-A was below that of macrophages from adrenalectomized control mice. These results suggest that other factors in addition to corticosterone may effect I-A expression by murine peritoneal macrophages. A survey of other neuropeptides and catecholamines indicated that the addition of ACTH or epinephrine to macrophage cultures resulted in a suppression of I-A expression.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalBrain Behavior and Immunity
Issue number1
Publication statusPublished - Jan 1 1993


All Science Journal Classification (ASJC) codes

  • Immunology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

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