The effect of anti-interleukin-2 receptor monoclonal antibody on allograft rejection

Robert L. Kirkman, Leslie V. Barrett, Glen N. Gaulton, Vicki E. Kelley, Walter Koltun, Frederick J. Schoen, Armelle Ythier, Terry B. Strom

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Abstract

During immune response to an allograft, activated T cells express a number of cell surface activation antigens, among them the membrane receptor for the lymphokine interleukin 2 (IL-2). As the IL-2 receptor is not present on resting T cells, it offers an attractive target for potentially specific immunosuppressive therapy. The rat monoclonal antibody M7/20, which binds to the murine IL-2 receptor, was studied for its effect on allograft survival in two H-2-incompatible strain combinations in inbred mice. Treatment with M7/20 for 10 days markedly prolonged survival of vascularized, hetero topic heart allografts in both strain combinations, with indefinite graft survival in 50% of recipients. The same treatment significantly prolonged skin allograft survival in one of the two combinations. The results support the important role of the IL-2 receptor in the mechanism of graft rejection and confirm its suitability as a target for immunosuppressive therapy in transplantation.

Original languageEnglish (US)
Pages (from-to)719-722
Number of pages4
JournalTransplantation
Volume40
Issue number6
DOIs
StatePublished - Jan 1 1985

All Science Journal Classification (ASJC) codes

  • Transplantation

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    Kirkman, R. L., Barrett, L. V., Gaulton, G. N., Kelley, V. E., Koltun, W., Schoen, F. J., Ythier, A., & Strom, T. B. (1985). The effect of anti-interleukin-2 receptor monoclonal antibody on allograft rejection. Transplantation, 40(6), 719-722. https://doi.org/10.1097/00007890-198512000-00029