The effect of aortic outflow on the quantification of mitral regurgitation by the flow convergence method.

J. Hopmeyer, Arnold Anthony Fontaine, S. Yang, R. A. Levine, A. P. Yoganathan

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effect of aortic outflow on the quantification of mitral regurgitation by the flow convergence method was investigated by both in vitro experiments and computational simulations. Digital analysis of the color Doppler M-mode images was compared with results obtained with laser Doppler anemometry, an engineering gold standard, and three-dimensional computational simulations. Regurgitant orifices of 3.2 and 6.4 mm in diameter were used with instantaneous aortic flow rates from 0 to 500 ml/sec, corresponding to net cardiac outputs of 0 to 5 L/min. In the absence of aortic outflow, a clear plateau was observed in plots of the calculated flow rate as a function of the distance from the orifice, indicating that there was a zone in which the hemispheric assumption was valid. As the aortic outflow was increased, the length of this plateau region decreased and then disappeared at high aortic flow rates. Farther from the orifice, beyond the plateau zone, the flow rate was overestimated and this overestimation increased with increasing aortic flow rate. Results showed excellent agreement between in vitro experiments and computational stimulations. This study demonstrated that aortic outflow has a dramatic effect on the flow convergence region and therefore must be considered in flow rate calculations.

Original languageEnglish (US)
Pages (from-to)44-57
Number of pages14
JournalJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
Volume9
Issue number1
DOIs
StatePublished - Jan 1 1996

Fingerprint

Mitral Valve Insufficiency
Cardiac Output
Lasers
Color
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

@article{3b72808fe7674b7cad01b0d7453cc817,
title = "The effect of aortic outflow on the quantification of mitral regurgitation by the flow convergence method.",
abstract = "The effect of aortic outflow on the quantification of mitral regurgitation by the flow convergence method was investigated by both in vitro experiments and computational simulations. Digital analysis of the color Doppler M-mode images was compared with results obtained with laser Doppler anemometry, an engineering gold standard, and three-dimensional computational simulations. Regurgitant orifices of 3.2 and 6.4 mm in diameter were used with instantaneous aortic flow rates from 0 to 500 ml/sec, corresponding to net cardiac outputs of 0 to 5 L/min. In the absence of aortic outflow, a clear plateau was observed in plots of the calculated flow rate as a function of the distance from the orifice, indicating that there was a zone in which the hemispheric assumption was valid. As the aortic outflow was increased, the length of this plateau region decreased and then disappeared at high aortic flow rates. Farther from the orifice, beyond the plateau zone, the flow rate was overestimated and this overestimation increased with increasing aortic flow rate. Results showed excellent agreement between in vitro experiments and computational stimulations. This study demonstrated that aortic outflow has a dramatic effect on the flow convergence region and therefore must be considered in flow rate calculations.",
author = "J. Hopmeyer and Fontaine, {Arnold Anthony} and S. Yang and Levine, {R. A.} and Yoganathan, {A. P.}",
year = "1996",
month = "1",
day = "1",
doi = "10.1016/S0894-7317(96)90103-0",
language = "English (US)",
volume = "9",
pages = "44--57",
journal = "Journal of the American Society of Echocardiography",
issn = "0894-7317",
publisher = "Mosby Inc.",
number = "1",

}

TY - JOUR

T1 - The effect of aortic outflow on the quantification of mitral regurgitation by the flow convergence method.

AU - Hopmeyer, J.

AU - Fontaine, Arnold Anthony

AU - Yang, S.

AU - Levine, R. A.

AU - Yoganathan, A. P.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - The effect of aortic outflow on the quantification of mitral regurgitation by the flow convergence method was investigated by both in vitro experiments and computational simulations. Digital analysis of the color Doppler M-mode images was compared with results obtained with laser Doppler anemometry, an engineering gold standard, and three-dimensional computational simulations. Regurgitant orifices of 3.2 and 6.4 mm in diameter were used with instantaneous aortic flow rates from 0 to 500 ml/sec, corresponding to net cardiac outputs of 0 to 5 L/min. In the absence of aortic outflow, a clear plateau was observed in plots of the calculated flow rate as a function of the distance from the orifice, indicating that there was a zone in which the hemispheric assumption was valid. As the aortic outflow was increased, the length of this plateau region decreased and then disappeared at high aortic flow rates. Farther from the orifice, beyond the plateau zone, the flow rate was overestimated and this overestimation increased with increasing aortic flow rate. Results showed excellent agreement between in vitro experiments and computational stimulations. This study demonstrated that aortic outflow has a dramatic effect on the flow convergence region and therefore must be considered in flow rate calculations.

AB - The effect of aortic outflow on the quantification of mitral regurgitation by the flow convergence method was investigated by both in vitro experiments and computational simulations. Digital analysis of the color Doppler M-mode images was compared with results obtained with laser Doppler anemometry, an engineering gold standard, and three-dimensional computational simulations. Regurgitant orifices of 3.2 and 6.4 mm in diameter were used with instantaneous aortic flow rates from 0 to 500 ml/sec, corresponding to net cardiac outputs of 0 to 5 L/min. In the absence of aortic outflow, a clear plateau was observed in plots of the calculated flow rate as a function of the distance from the orifice, indicating that there was a zone in which the hemispheric assumption was valid. As the aortic outflow was increased, the length of this plateau region decreased and then disappeared at high aortic flow rates. Farther from the orifice, beyond the plateau zone, the flow rate was overestimated and this overestimation increased with increasing aortic flow rate. Results showed excellent agreement between in vitro experiments and computational stimulations. This study demonstrated that aortic outflow has a dramatic effect on the flow convergence region and therefore must be considered in flow rate calculations.

UR - http://www.scopus.com/inward/record.url?scp=0029715388&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029715388&partnerID=8YFLogxK

U2 - 10.1016/S0894-7317(96)90103-0

DO - 10.1016/S0894-7317(96)90103-0

M3 - Article

C2 - 8679236

AN - SCOPUS:0029715388

VL - 9

SP - 44

EP - 57

JO - Journal of the American Society of Echocardiography

JF - Journal of the American Society of Echocardiography

SN - 0894-7317

IS - 1

ER -