The effect of calcium supplementation and Tanner Stage on bone density, content and area in teenage women

T. Lloyd, J. K. Martel, N. Rollings, M. B. Andon, H. Kulin, L. M. Demers, D. F. Eggli, K. Kieselhorst, V. M. Chinchilli

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

One hundred and twelve Caucasian girls, 11.9 ± 0.5 years of age at entry, were randomized into a 24-month, double-masked, placebo-controlled trial to determine the effect of calcium supplementation on bone mineral content, bone area and bone density. Supplementation was 500 mg calcium as calcium citrate malate (CCM) per day. Controls received placebo pills, and compliance of both groups averaged 72%. Bone mineral content, bone mineral area and bone mineral density of the lumbar spine and total body were measured by dual energy X-ray absorptiometry (DXA). Calcium intake from dietary sources averaged 983 mg/day for the entire study group. The supplemented group received, on average, an additional 360 mg calcium/day from CCM. At baseline and after 24 months, the two groups did not differ with respect to anthropometric measurements, urinary reproductive hormone levels or any measurement of pubertal progression. The supplemented group had greater increases of total body bone measures: content 39.9% versus 35.7% (p = 0.01), area 24.2% versus 22.5% (p = 0.15) and density 12.2% versus 10.1% (p = 0.005). Region-of-interest analyses showed that the supplemented group had greater gains compared with the control group for bone mineral density, content and area. In particular, in the lumbar spine and pelvis, the gains made by the supplemented group were 12%-24% greater than the increases made by the control group. Bone acquisition rates in the two study groups were further compared by subdividing the groups into those with below- or above-median values for Tanner score and dietary calcium intake. In subjects with below-median Tanner scores, bone acquisition was not affected by calcium supplementation or dietary calcium level. However, the calcium supplemented subjects with above-median Tanner had higher bone acqusition rates than the placebo group with above-median Tanner scores. Relative to the placebo group, the supplemented group had increased yearly gains of bone content, area and density which represented about 1.5% of adult female values. Such increases, if held to adult skeletal maturity, could provide protection against future risk of osteoporotic fractures.

Original languageEnglish (US)
Pages (from-to)276-283
Number of pages8
JournalOsteoporosis International
Volume6
Issue number4
DOIs
StatePublished - Jan 1 1996

Fingerprint

Bone Density
Calcium
Bone and Bones
Dietary Calcium
Placebos
Spine
Body Weights and Measures
Control Groups
Osteoporotic Fractures
Photon Absorptiometry
Pelvis
Compliance
Minerals
Hormones

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

Lloyd, T. ; Martel, J. K. ; Rollings, N. ; Andon, M. B. ; Kulin, H. ; Demers, L. M. ; Eggli, D. F. ; Kieselhorst, K. ; Chinchilli, V. M. / The effect of calcium supplementation and Tanner Stage on bone density, content and area in teenage women. In: Osteoporosis International. 1996 ; Vol. 6, No. 4. pp. 276-283.
@article{8f3e3cd4530b4a268e3448da45a64cd9,
title = "The effect of calcium supplementation and Tanner Stage on bone density, content and area in teenage women",
abstract = "One hundred and twelve Caucasian girls, 11.9 ± 0.5 years of age at entry, were randomized into a 24-month, double-masked, placebo-controlled trial to determine the effect of calcium supplementation on bone mineral content, bone area and bone density. Supplementation was 500 mg calcium as calcium citrate malate (CCM) per day. Controls received placebo pills, and compliance of both groups averaged 72{\%}. Bone mineral content, bone mineral area and bone mineral density of the lumbar spine and total body were measured by dual energy X-ray absorptiometry (DXA). Calcium intake from dietary sources averaged 983 mg/day for the entire study group. The supplemented group received, on average, an additional 360 mg calcium/day from CCM. At baseline and after 24 months, the two groups did not differ with respect to anthropometric measurements, urinary reproductive hormone levels or any measurement of pubertal progression. The supplemented group had greater increases of total body bone measures: content 39.9{\%} versus 35.7{\%} (p = 0.01), area 24.2{\%} versus 22.5{\%} (p = 0.15) and density 12.2{\%} versus 10.1{\%} (p = 0.005). Region-of-interest analyses showed that the supplemented group had greater gains compared with the control group for bone mineral density, content and area. In particular, in the lumbar spine and pelvis, the gains made by the supplemented group were 12{\%}-24{\%} greater than the increases made by the control group. Bone acquisition rates in the two study groups were further compared by subdividing the groups into those with below- or above-median values for Tanner score and dietary calcium intake. In subjects with below-median Tanner scores, bone acquisition was not affected by calcium supplementation or dietary calcium level. However, the calcium supplemented subjects with above-median Tanner had higher bone acqusition rates than the placebo group with above-median Tanner scores. Relative to the placebo group, the supplemented group had increased yearly gains of bone content, area and density which represented about 1.5{\%} of adult female values. Such increases, if held to adult skeletal maturity, could provide protection against future risk of osteoporotic fractures.",
author = "T. Lloyd and Martel, {J. K.} and N. Rollings and Andon, {M. B.} and H. Kulin and Demers, {L. M.} and Eggli, {D. F.} and K. Kieselhorst and Chinchilli, {V. M.}",
year = "1996",
month = "1",
day = "1",
doi = "10.1007/BF01623385",
language = "English (US)",
volume = "6",
pages = "276--283",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer London",
number = "4",

}

The effect of calcium supplementation and Tanner Stage on bone density, content and area in teenage women. / Lloyd, T.; Martel, J. K.; Rollings, N.; Andon, M. B.; Kulin, H.; Demers, L. M.; Eggli, D. F.; Kieselhorst, K.; Chinchilli, V. M.

In: Osteoporosis International, Vol. 6, No. 4, 01.01.1996, p. 276-283.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of calcium supplementation and Tanner Stage on bone density, content and area in teenage women

AU - Lloyd, T.

AU - Martel, J. K.

AU - Rollings, N.

AU - Andon, M. B.

AU - Kulin, H.

AU - Demers, L. M.

AU - Eggli, D. F.

AU - Kieselhorst, K.

AU - Chinchilli, V. M.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - One hundred and twelve Caucasian girls, 11.9 ± 0.5 years of age at entry, were randomized into a 24-month, double-masked, placebo-controlled trial to determine the effect of calcium supplementation on bone mineral content, bone area and bone density. Supplementation was 500 mg calcium as calcium citrate malate (CCM) per day. Controls received placebo pills, and compliance of both groups averaged 72%. Bone mineral content, bone mineral area and bone mineral density of the lumbar spine and total body were measured by dual energy X-ray absorptiometry (DXA). Calcium intake from dietary sources averaged 983 mg/day for the entire study group. The supplemented group received, on average, an additional 360 mg calcium/day from CCM. At baseline and after 24 months, the two groups did not differ with respect to anthropometric measurements, urinary reproductive hormone levels or any measurement of pubertal progression. The supplemented group had greater increases of total body bone measures: content 39.9% versus 35.7% (p = 0.01), area 24.2% versus 22.5% (p = 0.15) and density 12.2% versus 10.1% (p = 0.005). Region-of-interest analyses showed that the supplemented group had greater gains compared with the control group for bone mineral density, content and area. In particular, in the lumbar spine and pelvis, the gains made by the supplemented group were 12%-24% greater than the increases made by the control group. Bone acquisition rates in the two study groups were further compared by subdividing the groups into those with below- or above-median values for Tanner score and dietary calcium intake. In subjects with below-median Tanner scores, bone acquisition was not affected by calcium supplementation or dietary calcium level. However, the calcium supplemented subjects with above-median Tanner had higher bone acqusition rates than the placebo group with above-median Tanner scores. Relative to the placebo group, the supplemented group had increased yearly gains of bone content, area and density which represented about 1.5% of adult female values. Such increases, if held to adult skeletal maturity, could provide protection against future risk of osteoporotic fractures.

AB - One hundred and twelve Caucasian girls, 11.9 ± 0.5 years of age at entry, were randomized into a 24-month, double-masked, placebo-controlled trial to determine the effect of calcium supplementation on bone mineral content, bone area and bone density. Supplementation was 500 mg calcium as calcium citrate malate (CCM) per day. Controls received placebo pills, and compliance of both groups averaged 72%. Bone mineral content, bone mineral area and bone mineral density of the lumbar spine and total body were measured by dual energy X-ray absorptiometry (DXA). Calcium intake from dietary sources averaged 983 mg/day for the entire study group. The supplemented group received, on average, an additional 360 mg calcium/day from CCM. At baseline and after 24 months, the two groups did not differ with respect to anthropometric measurements, urinary reproductive hormone levels or any measurement of pubertal progression. The supplemented group had greater increases of total body bone measures: content 39.9% versus 35.7% (p = 0.01), area 24.2% versus 22.5% (p = 0.15) and density 12.2% versus 10.1% (p = 0.005). Region-of-interest analyses showed that the supplemented group had greater gains compared with the control group for bone mineral density, content and area. In particular, in the lumbar spine and pelvis, the gains made by the supplemented group were 12%-24% greater than the increases made by the control group. Bone acquisition rates in the two study groups were further compared by subdividing the groups into those with below- or above-median values for Tanner score and dietary calcium intake. In subjects with below-median Tanner scores, bone acquisition was not affected by calcium supplementation or dietary calcium level. However, the calcium supplemented subjects with above-median Tanner had higher bone acqusition rates than the placebo group with above-median Tanner scores. Relative to the placebo group, the supplemented group had increased yearly gains of bone content, area and density which represented about 1.5% of adult female values. Such increases, if held to adult skeletal maturity, could provide protection against future risk of osteoporotic fractures.

UR - http://www.scopus.com/inward/record.url?scp=0029784297&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029784297&partnerID=8YFLogxK

U2 - 10.1007/BF01623385

DO - 10.1007/BF01623385

M3 - Article

C2 - 8883115

AN - SCOPUS:0029784297

VL - 6

SP - 276

EP - 283

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 4

ER -