The effect of concentration ratio on tumor cell adhesion in shear flow

Yi Fu, Yang Wang, Fan Bai, Jie Wu, Ren Sun, Zu Rong Ding, Cheng Dong

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To study the different effects from different concentration ratios of polymorphonuclear neutrophil (PMN) to tumor cell (TC) on the process of tumor cell adhesion to endothelial cell (EC) in shear flow. Methods: PMNs and TCs with different concentration ratios (PMN-TC ratio) were added into the parallel plate flow chamber, and changes in the numbers of transient and accumulative adhered TCs on ECs at different shear rates (50 s-1, 100 s-1, 200 s-1) were analyzed. Results: The transient and accumulative adhesion of TCs on ECs at PMN-TC ratio of 3:1 significantly increased as compared to that at PMN-TC ratio of 1:1, especially under high shear flow condition (100 s-1 and 200 s-1). Moreover, in the 5 minute-observation period, the effect of PMN-TC ratio on TC adhered to ECs occurred earlier when the shear rate increased. Conclusions: The increase of PMN-TC concentration ratio can promote TC adhesion to ECs in shear flow, and the research findings provide significant references for studying TC metastasis in blood vessels and the target therapy of tumors.

Original languageEnglish (US)
Pages (from-to)392-396
Number of pages5
JournalYiyong Shengwu Lixue/Journal of Medical Biomechanics
Volume30
Issue number5
DOIs
StatePublished - Oct 1 2015

Fingerprint

Cell adhesion
Shear flow
Tumors
Shear deformation
Endothelial cells
Blood vessels
Adhesion
Cells

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

Fu, Yi ; Wang, Yang ; Bai, Fan ; Wu, Jie ; Sun, Ren ; Ding, Zu Rong ; Dong, Cheng. / The effect of concentration ratio on tumor cell adhesion in shear flow. In: Yiyong Shengwu Lixue/Journal of Medical Biomechanics. 2015 ; Vol. 30, No. 5. pp. 392-396.
@article{ed111a305e584c65b4a75483cbffb00f,
title = "The effect of concentration ratio on tumor cell adhesion in shear flow",
abstract = "Objective: To study the different effects from different concentration ratios of polymorphonuclear neutrophil (PMN) to tumor cell (TC) on the process of tumor cell adhesion to endothelial cell (EC) in shear flow. Methods: PMNs and TCs with different concentration ratios (PMN-TC ratio) were added into the parallel plate flow chamber, and changes in the numbers of transient and accumulative adhered TCs on ECs at different shear rates (50 s-1, 100 s-1, 200 s-1) were analyzed. Results: The transient and accumulative adhesion of TCs on ECs at PMN-TC ratio of 3:1 significantly increased as compared to that at PMN-TC ratio of 1:1, especially under high shear flow condition (100 s-1 and 200 s-1). Moreover, in the 5 minute-observation period, the effect of PMN-TC ratio on TC adhered to ECs occurred earlier when the shear rate increased. Conclusions: The increase of PMN-TC concentration ratio can promote TC adhesion to ECs in shear flow, and the research findings provide significant references for studying TC metastasis in blood vessels and the target therapy of tumors.",
author = "Yi Fu and Yang Wang and Fan Bai and Jie Wu and Ren Sun and Ding, {Zu Rong} and Cheng Dong",
year = "2015",
month = "10",
day = "1",
doi = "10.3871/j.1004-7220.2015.05.392",
language = "English (US)",
volume = "30",
pages = "392--396",
journal = "Yiyong Shengwu Lixue/Journal of Medical Biomechanics",
issn = "1004-7220",
publisher = "Biomedical Engineering Bianji Bu",
number = "5",

}

The effect of concentration ratio on tumor cell adhesion in shear flow. / Fu, Yi; Wang, Yang; Bai, Fan; Wu, Jie; Sun, Ren; Ding, Zu Rong; Dong, Cheng.

In: Yiyong Shengwu Lixue/Journal of Medical Biomechanics, Vol. 30, No. 5, 01.10.2015, p. 392-396.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of concentration ratio on tumor cell adhesion in shear flow

AU - Fu, Yi

AU - Wang, Yang

AU - Bai, Fan

AU - Wu, Jie

AU - Sun, Ren

AU - Ding, Zu Rong

AU - Dong, Cheng

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Objective: To study the different effects from different concentration ratios of polymorphonuclear neutrophil (PMN) to tumor cell (TC) on the process of tumor cell adhesion to endothelial cell (EC) in shear flow. Methods: PMNs and TCs with different concentration ratios (PMN-TC ratio) were added into the parallel plate flow chamber, and changes in the numbers of transient and accumulative adhered TCs on ECs at different shear rates (50 s-1, 100 s-1, 200 s-1) were analyzed. Results: The transient and accumulative adhesion of TCs on ECs at PMN-TC ratio of 3:1 significantly increased as compared to that at PMN-TC ratio of 1:1, especially under high shear flow condition (100 s-1 and 200 s-1). Moreover, in the 5 minute-observation period, the effect of PMN-TC ratio on TC adhered to ECs occurred earlier when the shear rate increased. Conclusions: The increase of PMN-TC concentration ratio can promote TC adhesion to ECs in shear flow, and the research findings provide significant references for studying TC metastasis in blood vessels and the target therapy of tumors.

AB - Objective: To study the different effects from different concentration ratios of polymorphonuclear neutrophil (PMN) to tumor cell (TC) on the process of tumor cell adhesion to endothelial cell (EC) in shear flow. Methods: PMNs and TCs with different concentration ratios (PMN-TC ratio) were added into the parallel plate flow chamber, and changes in the numbers of transient and accumulative adhered TCs on ECs at different shear rates (50 s-1, 100 s-1, 200 s-1) were analyzed. Results: The transient and accumulative adhesion of TCs on ECs at PMN-TC ratio of 3:1 significantly increased as compared to that at PMN-TC ratio of 1:1, especially under high shear flow condition (100 s-1 and 200 s-1). Moreover, in the 5 minute-observation period, the effect of PMN-TC ratio on TC adhered to ECs occurred earlier when the shear rate increased. Conclusions: The increase of PMN-TC concentration ratio can promote TC adhesion to ECs in shear flow, and the research findings provide significant references for studying TC metastasis in blood vessels and the target therapy of tumors.

UR - http://www.scopus.com/inward/record.url?scp=84947337517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947337517&partnerID=8YFLogxK

U2 - 10.3871/j.1004-7220.2015.05.392

DO - 10.3871/j.1004-7220.2015.05.392

M3 - Article

AN - SCOPUS:84947337517

VL - 30

SP - 392

EP - 396

JO - Yiyong Shengwu Lixue/Journal of Medical Biomechanics

JF - Yiyong Shengwu Lixue/Journal of Medical Biomechanics

SN - 1004-7220

IS - 5

ER -